Alpha-1 antitrypsin in autoimmune diseases: Roles and therapeutic prospects

被引：9

作者：

Sun, Rui ^{[1
,2
]}

Xu, Zhiqiang ^{[3
,4
]}

Zhu, Chenxi ^{[1
,2
]}

Chen, Tao ^{[1
,2
]}

Munoz, Luis E. ^{[5
,6
]}

Dai, Lunzhi ^{[3
,4
]}

Zhao, Yi ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Rheumatol & Immunol, Chengdu, Peoples R China

[2] Sichuan Univ, West China Hosp, Clin Inst Inflammat & Immunol CIII, Frontiers Sci Ctr Dis Related Mol Network, Chengdu, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Dept Rheumatol & Immunol, Chengdu, Peoples R China

[4] Sichuan Univ, West China Hosp, Dept Gen Practice, State Key Lab Biotherapy, Chengdu, Peoples R China

[5] Friedrich Alexander Univ Erlangen Nurnberg FAU, Dept Internal Med Rheumatol & Immunol 3, Erlangen, Germany

[6] Univ Klinikum Erlangen, Erlangen, Germany

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2022年 / 110卷

关键词：

-1 antitrypsin; A1AT; Autoimmune diseases; AATD; Treatment; OBSTRUCTIVE PULMONARY-DISEASE; ADDITIONAL N-GLYCOSYLATION; ISLET AMYLOID POLYPEPTIDE; HUMAN MONOCYTE ACTIVATION; NEUTROPHIL ELASTASE; GENE-THERAPY; AUGMENTATION THERAPY; ALPHA-ANTITRYPSIN; ALPHA(1)-ANTITRYPSIN DEFICIENCY; RHEUMATOID-ARTHRITIS;

D O I：

10.1016/j.intimp.2022.109001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Alpha-1 antitrypsin (A1AT) is a protease inhibitor in the serum. Its primary function is to inhibit the activity of a series of proteases, including proteinase 3, neutrophil elastase, metalloproteases, and cysteine-aspartate proteases. In addition, A1AT also has anti-inflammatory, anti-apoptotic, anti-oxidative stress, anti-viral, and antibacterial activities and plays essential roles in the regulation of tissue repair and lymphocyte differentiation and activation. The overactivation of the immune system characterizes the pathogenesis of autoimmune diseases. A1AT treatment shows beneficial effects on patients and animal models with autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. This review summarizes the functions and therapeutic prospects of A1AT in autoimmune diseases.

引用

页数：12

共 167 条

[11] N-Glycosylation and Biological Activity of Recombinant Human Alpha1-Antitrypsin Expressed in a Novel Human Neuronal Cell Line [J].

Blanchard, Veronique ;

Liu, Xi ;

Eigel, Susann ;

Kaup, Matthias ;

Rieck, Silke ;

Janciauskiene, Sabina ;

Sandig, Volker ;

Marx, Uwe ;

Walden, Peter ;

Tauber, Rudolf ;

Berger, Markus .

BIOTECHNOLOGY AND BIOENGINEERING, 2011, 108 (09) :2118-2128

[12] Efficacy of alpha1-antitrypsin augmentation therapy in conditions other than pulmonary emphysema [J].

Blanco, Ignacio ;

Lara, Beatriz ;

De Serres, Frederick .

ORPHANET JOURNAL OF RARE DISEASES, 2011, 6

[13] C-Terminal Alpha-1 Antitrypsin Peptide: A New Sepsis Biomarker with Immunomodulatory Function [J].

Blaurock, Nancy ;

Schmerler, Diana ;

Huenniger, Kerstin ;

Kurzai, Oliver ;

Ludewig, Katrin ;

Baier, Michael ;

Brunkhorst, Frank Martin ;

Imhof, Diana ;

Kiehntopf, Michael .

MEDIATORS OF INFLAMMATION, 2016, 2016

[14] Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis [J].

Bossuyt, Xavier ;

Tervaert, Jan-Willem Cohen ;

Arimura, Yoshihiro ;

Blockmans, Daniel ;

Felipe Flores-Suarez, Luis ;

Guillevin, Loic ;

Hellmich, Bernhard ;

Jennette, J. Charles ;

Kallenberg, Cees G. M. ;

Moiseev, Sergey ;

Novikov, Pavel ;

Radice, Antonella ;

Savige, Judith Anne ;

Sinico, Renato Alberto ;

Specks, Ulrich ;

van Paassen, Pieter ;

Zhao, Ming-hui ;

Rasmussen, Niels ;

Damoiseaux, Jan ;

Csernok, Elena ;

Jayne, David .

NATURE REVIEWS RHEUMATOLOGY, 2017, 13 (11) :683-692

[15] Development of Immature CD4+CD8+ T Cells Into Mature CD4+ T Cells Requires Alpha-1 Antitrypsin as Observed by Treatment in HIV-1 Infected and Uninfected Controls [J].

Bristow, Cynthia L. ;

Ferrando-Martinez, Sara ;

Ruiz-Mateos, Ezequiel ;

Leal, Manuel ;

Winston, Ronald .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019, 7

[16] Urinary peptidomics and bioinformatics for the detection of diabetic kidney disease [J].

Brondani, Leticia de Almeida ;

Soares, Ariana Aguiar ;

Recamonde-Mendoza, Mariana ;

Dall'Agnol, Angelica ;

Camargo, Joiza Lins ;

Monteiro, Karina Mariante ;

Silveiro, Sandra Pinho .

SCIENTIFIC REPORTS, 2020, 10 (01)

[17] Polyethylene glycol conjugation at Cys232 prolongs the half-life of α1 proteinase inhibitor [J].

Cantin, AM ;

Woods, DE ;

Cloutier, D ;

Dufour, EK ;

Leduc, R .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2002, 27 (06) :659-665

[18] HUMAN ALPHA-1-ANTITRYPSIN - CARBOHYDRATE ATTACHMENT AND SEQUENCE HOMOLOGY [J].

CARRELL, RW ;

JEPPSSON, JO ;

VAUGHAN, L ;

BRENNAN, SO ;

OWEN, MC ;

BOSWELL, DR .

FEBS LETTERS, 1981, 135 (02) :301-303

[19] Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic β-cell apoptosis [J].

Casas, Silvia ;

Gomis, Ramon ;

Gribble, Fiona M. ;

Altirriba, Jordi ;

Knuutila, Sakari ;

Novials, Anna .

DIABETES, 2007, 56 (09) :2284-2294

[20] Heterologous protein expression in the methylotrophic yeast Pichia pastoris [J].

Cereghino, JL ;

Cregg, JM .

FEMS MICROBIOLOGY REVIEWS, 2000, 24 (01) :45-66

← 1 2 3 4 5 6 7 8 9 10 →