Alpha-1 antitrypsin in autoimmune diseases: Roles and therapeutic prospects

被引：6
作者：
Sun, Rui [1 ,2 ]
Xu, Zhiqiang [3 ,4 ]
Zhu, Chenxi [1 ,2 ]
Chen, Tao [1 ,2 ]
Munoz, Luis E. [5 ,6 ]
Dai, Lunzhi [3 ,4 ]
Zhao, Yi [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp, Dept Rheumatol & Immunol, Chengdu, Peoples R China
[2] Sichuan Univ, West China Hosp, Clin Inst Inflammat & Immunol CIII, Frontiers Sci Ctr Dis Related Mol Network, Chengdu, Sichuan, Peoples R China
[3] Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Dept Rheumatol & Immunol, Chengdu, Peoples R China
[4] Sichuan Univ, West China Hosp, Dept Gen Practice, State Key Lab Biotherapy, Chengdu, Peoples R China
[5] Friedrich Alexander Univ Erlangen Nurnberg FAU, Dept Internal Med Rheumatol & Immunol 3, Erlangen, Germany
[6] Univ Klinikum Erlangen, Erlangen, Germany
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2022年 / 110卷
关键词：
-1 antitrypsin; A1AT; Autoimmune diseases; AATD; Treatment; OBSTRUCTIVE PULMONARY-DISEASE; ADDITIONAL N-GLYCOSYLATION; ISLET AMYLOID POLYPEPTIDE; HUMAN MONOCYTE ACTIVATION; NEUTROPHIL ELASTASE; GENE-THERAPY; AUGMENTATION THERAPY; ALPHA-ANTITRYPSIN; ALPHA(1)-ANTITRYPSIN DEFICIENCY; RHEUMATOID-ARTHRITIS;
D O I：
10.1016/j.intimp.2022.109001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Alpha-1 antitrypsin (A1AT) is a protease inhibitor in the serum. Its primary function is to inhibit the activity of a series of proteases, including proteinase 3, neutrophil elastase, metalloproteases, and cysteine-aspartate proteases. In addition, A1AT also has anti-inflammatory, anti-apoptotic, anti-oxidative stress, anti-viral, and antibacterial activities and plays essential roles in the regulation of tissue repair and lymphocyte differentiation and activation. The overactivation of the immune system characterizes the pathogenesis of autoimmune diseases. A1AT treatment shows beneficial effects on patients and animal models with autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. This review summarizes the functions and therapeutic prospects of A1AT in autoimmune diseases.
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页数：12
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