共 72 条
White Matter Microstructure in the Young Adult Brain Varies with Neighborhood Disadvantage in Adolescence
被引:18
作者:
Bell, Kristina L.
[1
]
Purcell, Juliann B.
[1
]
Harnett, Nathaniel G.
[1
,5
,6
]
Goodman, Adam M.
[1
,7
]
Mrug, Sylvie
[1
]
Schuster, Mark A.
[2
]
Elliott, Marc N.
[3
,8
]
Emery, Susan Tortolero
[4
]
Knight, David C.
[1
]
机构:
[1] Univ Alabama Birmingham, Dept Psychol, Birmingham, AL 35233 USA
[2] Harvard Med Sch, Boston Childrens Hosp, Boston, MA 02115 USA
[3] RAND Corp, Santa Monica, CA USA
[4] Univ Texas Hlth Sci Ctr Houston UTHlth, Sch Publ Hlth, Houston, TX USA
[5] McLean Hosp, Div Depress & Anxiety Disorders, Mclean, VA USA
[6] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA
[7] Univ Alabama Birmingham, Dept Neurol, UAB Stn, Birmingham, AL 35294 USA
[8] Kaiser Permanente Bernard J Tyson Sch Med, Pasadena, CA USA
来源:
关键词:
diffusion weighted imaging;
violence exposure;
family income;
adolescence;
NEURAL DEVELOPMENT DEPRIVATION;
STRIA TERMINALIS;
SOCIOECONOMIC-STATUS;
COGNITIVE FUNCTIONS;
CUMULATIVE RISK;
MENTAL-HEALTH;
INTEGRITY;
VIOLENCE;
AMYGDALA;
STRESS;
D O I:
10.1016/j.neuroscience.2021.05.012
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
disadvantage and community violence are common in poor, urban communities and are risk factors for emotional dysfunction. Emotional processes are supported by neural circuitry that includes the prefrontal cortex (PFC), hippocampus, amygdala, and hypothalamus. These brain regions are connected by white matter pathways that include the cingulum bundle, uncinate fasciculus, stria terminalis, and fornix. Emotional function varies with the microstructure of these white matter pathways. However, it is not clear whether the microstructure of these pathways varies with risk factors for emotional dysfunction (e.g., neighborhood disadvantage and violence exposure). Therefore, determining the relationships between neighborhood disadvantage, violence exposure, and white matter microstructure may offer insight into the neural mechanisms by which adverse life experiences alter developing neural systems. The current study investigated the association that exposure to neighborhood disadvantage and violence have with the quantitative anisotropy (QA), a measure of the amount of directional water diffusion, of the cingulum bundle, uncinate fasciculus, stria terminalis, and fornix. Neighborhood disadvantage (Mage = 11.20) and violence exposure (MW1age = 11.20; MW2age = 13.05; MW3age = 16.20; MW4age = 19.25) were assessed during adolescence and participants returned for magnetic resonance imaging as young adults (N = 303; Mage = 20.25, SD = 1.55), during which diffusion weighted brain images were collected. The QA of the cingulum bundle, uncinate fasciculus, and stria terminalis/fornix varied negatively with neighborhood disadvantage such that the QA of these white matter tracts decreased as neighborhood disadvantage increased. Violence exposure was not related to QA in any tract (i.e., cingulum bundle, uncinate fasciculus, and stria terminalis/fornix) after correction for multiple comparisons. These results suggest that an adolescent's neighborhood may play an important role in the microstructure (i.e., QA) of white matter pathways that connect brain regions that support emotional function. (c) 2021 IBRO. Published by Elsevier Ltd. All rights reserved.
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页码:162 / 172
页数:11
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