Shiga toxin-mediated retrograde delivery of a topoisomerase I inhibitor prodrug

被引：65
作者：
El Alaoui, Abdessamad
Schmidt, Frederic
Amessou, Mohamed
Sarr, Marianne
Decaudin, Didier
Florent, Jean-Claude
Johannes, Ludger
机构：
[1] Inst Curie, Ctr Rech, CNRS, UMR 176, F-75248 Paris 05, France
[2] Inst Curie, Ctr Rech, CNRS, UMR 144, F-75248 Paris, France
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 34期
关键词：
antitumor agents; drug delivery; prodrugs retrograde; transport; Shiga toxin;
D O I：
10.1002/anie.200701270
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) A retrograde strategy: An innovative cancer-cell delivery concept exploits the naturally evolved characteristics of the Shiga toxin B-subunit (STxB) for the intracellular activation of a newly synthesized prodrug at the level of the biosynthetic/secretory pathway (see picture). Retrograde prodrug targeting allows its slow release, which should sustain the presence of the active principle in dividing tumor cells. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：6469 / 6472
页数：4
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