Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents

被引：305

作者：

Kumar, SK ^{[1
]}

Hager, E ^{[1
]}

Pettit, C ^{[1
]}

Gurulingappa, H ^{[1
]}

Davidson, NE ^{[1
]}

Khan, SR ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Div Expt Therapeut, Baltimore, MD 21231 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 46卷 / 14期

关键词：

D O I：

10.1021/jm030213+

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast cancer cells compared to normal breast cells than other known chalcones.

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收藏

页码：2813 / 2815

页数：3

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