The current landscape in Alzheimer's disease research and drug discovery

被引:23
作者
Devenish, Sean R. A. [1 ]
机构
[1] Fluid Analyt, Cambridge, England
关键词
ADUCANUMAB;
D O I
10.1016/j.drudis.2020.04.002
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:943 / 945
页数:3
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共 10 条
[1]   Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions [J].
Arosio, Paolo ;
Mueller, Thomas ;
Rajah, Luke ;
Yates, Emma V. ;
Aprile, Francesco A. ;
Zhang, Yingbo ;
Cohen, Samuel I. A. ;
White, Duncan A. ;
Herling, Therese W. ;
De Genst, Erwin J. ;
Linse, Sara ;
Vendruscolo, Michele ;
Dobson, Christopher M. ;
Knowles, Tuomas P. J. .
ACS NANO, 2016, 10 (01) :333-341
[2]   Alzheimer's Disease: Past, Present, and Future [J].
Bondi, Mark W. ;
Edmonds, Emily C. ;
Salmon, David P. .
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2017, 23 (9-10) :818-831
[3]   A three-dimensional human neural cell culture model of Alzheimer's disease [J].
Choi, Se Hoon ;
Kim, Young Hye ;
Hebisch, Matthias ;
Sliwinski, Christopher ;
Lee, Seungkyu ;
D'Avanzo, Carla ;
Chen, Hechao ;
Hooli, Basavaraj ;
Asselin, Caroline ;
Muffat, Julien ;
Klee, Justin B. ;
Zhang, Can ;
Wainger, Brian J. ;
Peitz, Michael ;
Kovacs, Dora M. ;
Woolf, Clifford J. ;
Wagner, Steven L. ;
Tanzi, Rudolph E. ;
Kim, Doo Yeon .
NATURE, 2014, 515 (7526) :274-U293
[4]   ALZHEIMERS-DISEASE - THE AMYLOID CASCADE HYPOTHESIS [J].
HARDY, JA ;
HIGGINS, GA .
SCIENCE, 1992, 256 (5054) :184-185
[5]   Clinical trials of new drugs for Alzheimer disease [J].
Huang, Li-Kai ;
Chao, Shu-Ping ;
Hu, Chaur-Jong .
JOURNAL OF BIOMEDICAL SCIENCE, 2020, 27 (01)
[6]   SDS-PAGE analysis of Aβ oligomers is disserving research into Alzheimer's disease: appealing for ESI-IM-MS [J].
Pujol-Pina, Rosa ;
Vilaprinyo-Pascual, Slvia ;
Mazzucato, Roberta ;
Arcella, Annalisa ;
Vilaseca, Marta ;
Orozco, Modesto ;
Carulla, Natalia .
SCIENTIFIC REPORTS, 2015, 5
[7]   A resurrection of aducanumab for Alzheimer's disease [J].
Schneider, Lon .
LANCET NEUROLOGY, 2020, 19 (02) :111-112
[8]   The antibody aducanumab reduces Aβ plaques in Alzheimer's disease [J].
Sevigny, Jeff ;
Chiao, Ping ;
Bussiere, Thierry ;
Weinreb, Paul H. ;
Williams, Leslie ;
Maier, Marcel ;
Dunstan, Robert ;
Salloway, Stephen ;
Chen, Tianle ;
Ling, Yan ;
O'Gorman, John ;
Qian, Fang ;
Arastu, Mahin ;
Li, Mingwei ;
Chollate, Sowmya ;
Brennan, Melanie S. ;
Quintero-Monzon, Omar ;
Scannevin, Robert H. ;
Arnold, H. Moore ;
Engber, Thomas ;
Rhodes, Kenneth ;
Ferrero, James ;
Hang, Yaming ;
Mikulskis, Alvydas ;
Grimm, Jan ;
Hock, Christoph ;
Nitsch, Roger M. ;
Sandrock, Alfred .
NATURE, 2016, 537 (7618) :50-56
[9]   Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease [J].
Shinohara, Mitsuru ;
Fujioka, Shinsuke ;
Murray, Melissa E. ;
Wojtas, Aleksandra ;
Baker, Matthew ;
Rovelet-Lecrux, Anne ;
Rademakers, Rosa ;
Das, Pritam ;
Parisi, Joseph E. ;
Graff-Radford, Neill R. ;
Petersen, Ronald C. ;
Dickson, Dennis W. ;
Bu, Guojun .
BRAIN, 2014, 137 :1533-1549
[10]   Strategies Targeting Soluble β-Amyloid Oligomers and their Application to Early Diagnosis of Alzheimer's Disease [J].
Zeng, Fantian ;
Li, Yuyan ;
Xu, Yungen ;
Yang, Jian ;
Liu, Zhengshi ;
Li, Xiaofang ;
Ren, Longfei .
CURRENT ALZHEIMER RESEARCH, 2019, 16 (12) :1132-1142