Induced Pluripotent Stem Cells for the Treatment of Liver Diseases: Novel Concepts

被引：9
作者：
Yao, Jia [1 ,3 ]
Yu, Yue [2 ]
Nyberg, Scott L. [1 ,4 ]
机构：
[1] Mayo Clin, William J von Liebig Ctr Transplantat & Clin Regen, Rochester, MN USA
[2] Nanjing Med Univ, Chinese Acad Med Sci, Affiliated Hosp 1, Hepatobiliary Ctr,Key Lab Liver Transplantat,NHC K, Nanjing, Peoples R China
[3] Lanzhou Univ, Hosp 1, Clin Res & Project Management Off, Lanzhou, Peoples R China
[4] Mayo Clin, William J von Liebig Ctr Transplantat & Clin Regen, 200 First St SW, Rochester, MN 55905 USA
来源：
CELLS TISSUES ORGANS | 2022年 / 211卷 / 04期
基金：
美国国家卫生研究院; 中国国家自然科学基金;
关键词：
Induced pluripotent stem cells; Liver diseases; Liver transplantation; Regeneration medicine; Blastocyst complementation; HEPATOCYTE-LIKE CELLS; IN-VITRO DIFFERENTIATION; HIGH-GRADE PATIENT; GENE CORRECTION; REGENERATIVE MEDICINE; METABOLIC-DISORDERS; POTENTIAL TREATMENT; IPSC LINE; TRANSPLANTATION; GENERATION;
D O I：
10.1159/000508182
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Millions of people worldwide with incurable liver disease die because of inadequate treatment options and limited availability of donor organs for liver transplantation. Regenerative medicine as an innovative approach to repairing and replacing cells, tissues, and organs is undergoing a major revolution due to the unprecedented need for organs for patients around the world. Induced pluripotent stem cells (iPSCs) have been widely studied in the field of liver regeneration and are considered to be the most promising candidate therapies. This review will conclude the current state of efforts to derive human iPSCs for potential use in the modeling and treatment of liver disease.
引用
收藏
页码：368 / 384
页数：17
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