Sequence Determination of the Heavy-Chain Constant Region in Four Immunoglobulin Classes of Mongolian Gerbils (Meriones unguiculatus)

被引：5

作者：

Ukaji, Takao ^{[1
]}

Sumiyama, Daisuke ^{[1
]}

Kai, Osamu ^{[1
]}

机构：

[1] Nihon Univ, Coll Bioresource Sci, Dept Anim Sci & Resources, Fujisawa, Kanagawa 2520880, Japan

来源：

EXPERIMENTAL ANIMALS | 2012年 / 61卷 / 02期

关键词：

cDNA; immunoglobulin heavy-chain constant (IGHC); Mongolian gerbil; RT-PCR; GENE FAMILY; EXPRESSION; CELLS;

D O I：

10.1538/expanim.61.99

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

We determined partial cDNA sequences of four immunoglobulin (Ig) classes-IgM, IgG1, IgE, and IgA of Mongolian gerbil (Meriones unguiculatus). Each deduced Ig heavy-chain constant (IGHC) region-C mu, C gamma 1, C epsilon, and C alpha-is structurally similar to its counterparts in the mouse and rat, and phylogenetic analysis suggests that the gerbil Igs are evolutionarily close to their counterparts. In spite of the high sequence homology to the other rodent C gamma sequences, the gerbil C gamma 1 sequence differs from our previously reported C gamma 2. This result indicates that the gerbil has at least two IgG subclasses. These four gerbil IGHC cDNA sequences will be useful for determining gerbil Ig isotypes and examining the expression of gerbil Ig mRNAs in response to parasitic and bacterial infections.

引用

页码：99 / 107

页数：9

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