Silica Nanoparticles in Transmucosal Drug Delivery

被引：46
作者：
Ways, Twana Mohammed M. [1 ,2 ]
Ng, Keng Wooi [3 ]
Lau, Wing Man [3 ]
Khutoryanskiy, Vitaliy V. [1 ]
机构：
[1] Univ Reading, Reading Sch Pharm, Reading RG6 6AD, Berks, England
[2] Univ Sulaimani, Coll Pharm, Sulaimani 46001, Iraq
[3] Newcastle Univ, Fac Med Sci, Sch Pharm, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
来源：
PHARMACEUTICS | 2020年 / 12卷 / 08期
关键词：
silica nanoparticles; organosilica; transmucosal drug delivery; mucoadhesion; mucosal penetration; ONE-POT SYNTHESIS; MESOPOROUS SILICA; SURFACE FUNCTIONALIZATION; ORGANOSILICA NANOPARTICLES; DOSAGE FORMS; POLYMERIC NANOPARTICLES; BIOLOGICAL APPLICATIONS; MUCOADHESIVE CARRIER; IN-VITRO; THIOL;
D O I：
10.3390/pharmaceutics12080751
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Transmucosal drug delivery includes the administration of drugs via various mucous membranes, such as gastrointestinal, nasal, ocular, and vaginal mucosa. The use of nanoparticles in transmucosal drug delivery has several advantages, including the protection of drugs against the harsh environment of the mucosal lumens and surfaces, increased drug residence time, and enhanced drug absorption. Due to their relatively simple synthetic methods for preparation, safety profile, and possibilities of surface functionalisation, silica nanoparticles are highly promising for transmucosal drug delivery. This review provides a description of silica nanoparticles and outlines the preparation methods for various core and surface-functionalised silica nanoparticles. The relationship between the functionalities of silica nanoparticles and their interactions with various mucous membranes are critically analysed. Applications of silica nanoparticles in transmucosal drug delivery are also discussed.
引用
收藏
页码：1 / 25
页数：24
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