Stressed out about obesity: IRE1α-XBP1 in metabolic disorders

被引：74
作者：
Sha, Haibo [1 ]
He, Yin [2 ]
Yang, Liu [3 ]
Qi, Ling [1 ,2 ,3 ]
机构：
[1] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
[2] Cornell Univ, Grad Program Genet & Dev, Ithaca, NY USA
[3] Cornell Univ, Grad Program Biochem Mol & Cell Biol, Ithaca, NY USA
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2011年 / 22卷 / 09期
基金：
美国国家卫生研究院;
关键词：
ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; ER STRESS; INSULIN-RESISTANCE; REGULATORY SUBUNIT; HEPATIC STEATOSIS; BAX INHIBITOR-1; MESSENGER-RNAS; KAPPA-B; ACTIVATION;
D O I：
10.1016/j.tem.2011.05.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The global obesity epidemic is associated with a series of health-threatening diseases including type 2 diabetes. Accumulating evidence suggest that the physiology and homeostasis of the endoplasmic reticulum (ER) is intimately involved in the underlying mechanisms linking obesity and diabetes. Specifically, recent studies indicate a crucial role for the inositol-requiring enzyme 1 alpha (IRE1 alpha)/X-box binding protein 1 (XBP1) pathway, the most conserved branch of the unfolded protein response (UPR), in glucose and lipid metabolism as well as in insulin function. Focusing on the IRE1 alpha-XBP1 pathway, we review recent advances in our understanding of the role of UPR in obesity and obesity-associated metabolic disorders.
引用
收藏
页码：374 / 381
页数：8
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