Pediatric oncology research in low income countries: Ethical concepts and challenges

被引：17

作者：

Denburg, Avram E. ^{[1
]}

Joffe, Steven ^{[2
,3
]}

Gupta, Sumit ^{[1
]}

Howard, Scott C. ^{[4
]}

Ribeiro, Raul C. ^{[4
]}

Antillon, Federico A. ^{[5
]}

Vasquez, Roberto ^{[6
]}

Sung, Lillian ^{[1
]}

机构：

[1] Hosp Sick Children, Div Haematol Oncol, Dept Pediat Oncol, Toronto, ON M5G 1X8, Canada

[2] Dana Farber Canc Inst, Boston, MA 02115 USA

[3] Dept Med, Boston, MA USA

[4] St Jude Childrens Hosp, Dept Oncol, Memphis, TN 38105 USA

[5] Unidad Nacl Oncol Pediat, Guatemala City, Guatemala

[6] Benjamin Bloom Natl Childrens Hosp, San Salvador, El Salvador

来源：

PEDIATRIC BLOOD & CANCER | 2012年 / 58卷 / 04期

基金：

加拿大健康研究院;

关键词：

ethics review; informed consent; low income countries; pediatric oncology; research ethics; standard of care; trial benefits; ACUTE LYMPHOBLASTIC-LEUKEMIA; INTERNATIONAL RESEARCH; CLINICAL-RESEARCH; CHILDHOOD; INTERVENTIONS; ESTABLISHMENT; HELSINKI; OUTCOMES; TRIALS; CANCER;

D O I：

10.1002/pbc.23419

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Uneven strides in research and care have led to discrepancies in childhood cancer outcomes between high and low income countries (LICs). Collaborative research may help improve outcomes in LICs by generating knowledge for local scientific communities, augmenting knowledge translation, and fostering context-specific evaluation of treatment protocols. However, the risks of such research have received little attention. This paper investigates the relationship between pediatric oncology research in LICs and four core issues in the ethics literature: standard of care, trial benefits, ethics review, and informed consent. Our aims are to highlight the importance of this field and the need for further inquiry. Pediatr Blood Cancer 2012; 58: 492497. (c) 2011 Wiley Periodicals, Inc.

引用

页码：492 / 497

页数：6

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