Bovine papillomavirus type 4 L1 gene transfection in a Drosophila S2 cell expression system:: Absence of L1 protein expression

被引：0

作者：

Bentim Goes, Luiz Gustavo ^{[1
]}

de Freitas, Antonio Carlos ^{[1
,3
]}

Ferraz, Oilita Pereira ^{[1
]}

Rieger, Tania Tassinari ^{[2
]}

dos Santos, Jose Ferreira ^{[2
]}

Pereira, Alexandre ^{[1
]}

Becak, Willy ^{[1
,2
]}

Lindsey, Charles J. ^{[4
]}

Stocco, Rita de Cassia ^{[1
]}

机构：

[1] Inst Butantan, Genet Lab, BR-0503900 Sao Paulo, Brazil

[2] Univ Fed Pernambuco, Dept Genet, Recife, PE, Brazil

[3] Univ Fed Pernambuco, Lab Imunopatol Keizo Asami, Recife, PE, Brazil

[4] Univ Fed Sao Paulo, Dept Biofis, Sao Paulo, Brazil

来源：

BRAZILIAN JOURNAL OF MICROBIOLOGY | 2008年 / 39卷 / 01期

关键词：

bovine papillomavirus; BPV4; S2 expression cells;

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The development of a bovine papillomavirus (BPV) vaccine is an outstanding challenge. BPV protein L1 gene transfection in the Drosophila melanogaster S2 cell expression system failed to produce L1 protein notwithstanding correct L1 gene insertion. Severe genetic inbalance in the host cell line, including cytogenetic alterations, may account for the lack of protein expression.

引用

页码：1 / 4

页数：4

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