Chaetoglobosin A, an inhibitor of bleb formation on K562 cells induced by phorbol 12,13-dibutyrate

被引：0

作者：

Ko, HR

Kim, BY

Ahn, SC

Oh, WK

Kim, JH

Lee, HS

Kim, HM

Han, SB

Mheen, TI

Ahn, JS

机构：

[1] Korea Res inst Biosci & Biotechnol, Cellular Response Modifier Res Unit, Taejon 305600, South Korea

[2] Korea Res inst Biosci & Biotechnol, Genet Resources Ctr, Taejon 305600, South Korea

来源：

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 1998年 / 8卷 / 06期

关键词：

bleb formation; inhibitor; PDBu; K562; cells; chaetoglobosin A;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In the course of screening for the substances suppressing bleb formation of K562 cell induced by phorbol 12,13-dibutyrate (PDBu), an inhibitor, chaetoglobosin A (CgA) was isolated from a cultured broth of unidentified fungus. CgA showed a strong inhibitory activity with the IC50 value of 60 pM against bIeb formation on K562 cells induced by PDBu, but it did not inhibit the activity of protein kinase C (PKC) in vitro. The inhibitory activity of CgA might be due to the modulation of actin filaments on the cell membrane. CgA exhibited strong cytotoxicity against various human cancer cell lines.

引用

页码：705 / 709

页数：5

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