Chaetoglobosin A, an inhibitor of bleb formation on K562 cells induced by phorbol 12,13-dibutyrate

被引：0
|
作者：
Ko, HR
Kim, BY
Ahn, SC
Oh, WK
Kim, JH
Lee, HS
Kim, HM
Han, SB
Mheen, TI
Ahn, JS
机构：
[1] Korea Res inst Biosci & Biotechnol, Cellular Response Modifier Res Unit, Taejon 305600, South Korea
[2] Korea Res inst Biosci & Biotechnol, Genet Resources Ctr, Taejon 305600, South Korea
来源：
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 1998年 / 8卷 / 06期
关键词：
bleb formation; inhibitor; PDBu; K562; cells; chaetoglobosin A;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In the course of screening for the substances suppressing bleb formation of K562 cell induced by phorbol 12,13-dibutyrate (PDBu), an inhibitor, chaetoglobosin A (CgA) was isolated from a cultured broth of unidentified fungus. CgA showed a strong inhibitory activity with the IC50 value of 60 pM against bIeb formation on K562 cells induced by PDBu, but it did not inhibit the activity of protein kinase C (PKC) in vitro. The inhibitory activity of CgA might be due to the modulation of actin filaments on the cell membrane. CgA exhibited strong cytotoxicity against various human cancer cell lines.
引用
收藏
页码：705 / 709
页数：5
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