15N Heteronuclear Chemical Exchange Saturation Transfer MRI

被引：16

作者：

Zeng, Haifeng ^{[1
,3
]}

Xu, Jiadi ^{[1
,3
]}

Yadav, Nirbhay N. ^{[1
,3
]}

McMahon, Michael T. ^{[1
,3
]}

Harden, Bradley ^{[2
]}

Frueh, Dominique ^{[2
]}

van Zijl, Peter C. M. ^{[1
,3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Biophys & Biophys Chem, Baltimore, MD 21205 USA

[3] Kennedy Krieger Res Inst, FM Kirby Res Ctr Funct Brain Imaging, Baltimore, MD 21205 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 35期

基金：

美国国家卫生研究院;

关键词：

AMIDE PROTON-TRANSFER; CONTRAST AGENTS; HUMAN BRAIN; IN-VIVO; FLEX TRANSFER; METABOLISM; GLUCOSE; CANCER; TUMORS; WATER;

D O I：

10.1021/jacs.6b06421

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A two-step heteronuclear enhancement approach was combined with chemical exchange saturation transfer (CEST) to magnify N-15 MRI signal of molecules through indirect detection via water protons. Previous CEST studies have been limited to radiofrequency (rf) saturation transfer or excitation transfer employing protons. Here, the signal of N-15 is detected indirectly through the water signal by first inverting selectively protons that are scalar-coupled to N-15 in the urea molecule, followed by chemical exchange of the amide proton to bulk water. In addition to providing a small sensitivity enhancement, this approach can be used to monitor the exchange rates and thus the pH sensitivity of the participating N-15-bound protons.

引用

页码：11136 / 11139

页数：4

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