A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient

被引:0
作者
Grove, John [1 ]
Meier, Casey [1 ]
Youssef, Bahaaeldin [2 ]
Costello, Patrick [2 ]
机构
[1] Lincoln Mem Univ, DeBusk Coll Osteopath Med, Pathol, Knoxville, TN 37923 USA
[2] East Tennessee State Univ, Quillen Coll Med, Pathol, Johnson City, TN USA
关键词
immunohistochemical; bronchoscopy; lung mass; pediatrics; granular cell tumor;
D O I
10.7759/cureus.21558
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Granular cell tumors (GCTs) are rare neoplasms of neuroectodermal origin characterized by large polygonal cells with abundant eosinophilic and granular cytoplasm. GCTs rarely affect the lungs, with only a few cases reported in the literature. The pathophysiology of this Schwann cell-derived condition is not well understood but is thought to be due to recurring genetic mutations. GCTs have been linked with Noonan syndrome. Here, we report the case of a 17-year-old caucasian male who presented with partial upper airway obstruction due to a GCT. This case promotes awareness among pathologists and clinicians for this condition in the workup of patients presenting with upper airway obstruction.
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页数:3
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共 9 条
  • [1] Multiple granular cell tumours in a patient with Noonan's syndrome and juvenile myelomonocytic leukaemia
    Castagna, J.
    Clerc, J.
    Dupond, A. -S.
    Laresche, C.
    [J]. ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE, 2017, 144 (11): : 705 - 711
  • [2] Pulmonary Granular Cell Tumors A Study of 4 Cases Including a Malignant Phenotype
    Davis, Richard
    Deak, Kristen
    Glass, Carolyn H.
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2019, 43 (10) : 1397 - 1402
  • [3] GRANULAR-CELL TUMORS OF THE LUNG - CLINICOPATHOLOGICAL STUDY OF 20 CASES
    DEAVERS, M
    GUINEE, D
    KOSS, MN
    TRAVIS, WD
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1995, 19 (06) : 627 - 635
  • [4] Granular cell tumor experience at a comprehensive cancer center
    Moten, Ambria S.
    Movva, Sujana
    von Mehren, Margaret
    Wu, Hong
    Esnaola, Nestor F.
    Reddy, Sanjay S.
    Farma, Jeffrey M.
    [J]. JOURNAL OF SURGICAL RESEARCH, 2018, 226 : 1 - 7
  • [5] Neelon D, 2021, GRANULAR CELL TUMOR
  • [6] Radaelli Franco, 2009, Gastroenterol Hepatol (N Y), V5, P798
  • [7] Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11
    Schrader, K. A.
    Nelson, T. N.
    De Luca, A.
    Huntsman, D. G.
    McGillivray, B. C.
    [J]. CLINICAL GENETICS, 2009, 75 (02) : 185 - 189
  • [8] Singh VA, 2015, SINGAP MED J, V56, P513, DOI 10.11622/smedj.2015136
  • [9] Recurrent granular cell tumor: How to treat
    Yimaz, Asu Deniz
    Unlu, R. Erkin
    Orbay, Hakan
    Sensoz, Omer
    [J]. JOURNAL OF CRANIOFACIAL SURGERY, 2007, 18 (05) : 1187 - 1189