A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient

被引:2
作者
Grove, John [1 ]
Meier, Casey [1 ]
Youssef, Bahaaeldin [2 ]
Costello, Patrick [2 ]
机构
[1] Lincoln Mem Univ, DeBusk Coll Osteopath Med, Pathol, Knoxville, TN 37923 USA
[2] East Tennessee State Univ, Quillen Coll Med, Pathol, Johnson City, TN USA
关键词
immunohistochemical; bronchoscopy; lung mass; pediatrics; granular cell tumor;
D O I
10.7759/cureus.21558
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Granular cell tumors (GCTs) are rare neoplasms of neuroectodermal origin characterized by large polygonal cells with abundant eosinophilic and granular cytoplasm. GCTs rarely affect the lungs, with only a few cases reported in the literature. The pathophysiology of this Schwann cell-derived condition is not well understood but is thought to be due to recurring genetic mutations. GCTs have been linked with Noonan syndrome. Here, we report the case of a 17-year-old caucasian male who presented with partial upper airway obstruction due to a GCT. This case promotes awareness among pathologists and clinicians for this condition in the workup of patients presenting with upper airway obstruction.
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页数:3
相关论文
共 9 条
[1]   Multiple granular cell tumours in a patient with Noonan's syndrome and juvenile myelomonocytic leukaemia [J].
Castagna, J. ;
Clerc, J. ;
Dupond, A. -S. ;
Laresche, C. .
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE, 2017, 144 (11) :705-711
[2]   Pulmonary Granular Cell Tumors A Study of 4 Cases Including a Malignant Phenotype [J].
Davis, Richard ;
Deak, Kristen ;
Glass, Carolyn H. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2019, 43 (10) :1397-1402
[3]   GRANULAR-CELL TUMORS OF THE LUNG - CLINICOPATHOLOGICAL STUDY OF 20 CASES [J].
DEAVERS, M ;
GUINEE, D ;
KOSS, MN ;
TRAVIS, WD .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1995, 19 (06) :627-635
[4]   Granular cell tumor experience at a comprehensive cancer center [J].
Moten, Ambria S. ;
Movva, Sujana ;
von Mehren, Margaret ;
Wu, Hong ;
Esnaola, Nestor F. ;
Reddy, Sanjay S. ;
Farma, Jeffrey M. .
JOURNAL OF SURGICAL RESEARCH, 2018, 226 :1-7
[5]  
Neelon D, 2021, GRANULAR CELL TUMOR
[6]  
Radaelli Franco, 2009, Gastroenterol Hepatol (N Y), V5, P798
[7]   Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11 [J].
Schrader, K. A. ;
Nelson, T. N. ;
De Luca, A. ;
Huntsman, D. G. ;
McGillivray, B. C. .
CLINICAL GENETICS, 2009, 75 (02) :185-189
[8]  
Singh VA, 2015, SINGAP MED J, V56, P513, DOI 10.11622/smedj.2015136
[9]   Recurrent granular cell tumor: How to treat [J].
Yimaz, Asu Deniz ;
Unlu, R. Erkin ;
Orbay, Hakan ;
Sensoz, Omer .
JOURNAL OF CRANIOFACIAL SURGERY, 2007, 18 (05) :1187-1189