Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis

被引：458
作者：
Badawi, Alaa [1 ]
Ryoo, Seung Gwan [2 ]
机构：
[1] Publ Hlth Agcy Canada, Publ Hlth Risk Sci Div, 180 Queen St West, Toronto, ON M5V 3L7, Canada
[2] Univ Toronto, Fac Arts & Sci, Toronto, ON, Canada
来源：
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2016年 / 49卷
关键词：
Diabetes mellitus; Cardiovascular diseases; Obesity; Middle East respiratory syndrome coronavirus (MERS-CoV); Systematic review; INFLUENZA-A H1N1; SAUDI-ARABIA; CLINICAL CHARACTERISTICS; HOSPITALIZED-PATIENTS; RISK-FACTORS; IMMUNIZATION; INFECTIONS; PREVENTION; PNEUMONIA; RIBAVIRIN;
D O I：
10.1016/j.ijid.2016.06.015
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The Middle East respiratory syndrome coronavirus (MERS-CoV) is associated with life-threatening severe illnesses and a mortality rate of approximately 35%, particularly in patients with underlying comorbidities. A systematic analysis of 637 MERS-CoV cases suggests that diabetes and hypertension are equally prevalent in approximately 50% of the patients. Cardiac diseases are present in 30% and obesity in 16% of the cases. These conditions down-regulate the synthesis of proinflammatory cytokines and impair the host's innate and humoral immune systems. In conclusion, protection against MERS-CoV and other respiratory infections can be improved if public health vaccination strategies are tailored to target persons with chronic disorders. Crown Copyright (C) 2016 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
引用
收藏
页码：129 / 133
页数：5
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