Immune Thrombocytopenia Induced by the Chimpanzee Adenovirus-Vectored Vaccine against SARS-CoV-2 Infection

被引：6

作者：

Liao, Po-Wei ^{[1
]}

Teng, Chieh-Lin Jerry ^{[1
,2
,3
]}

Chou, Cheng-Wei ^{[1
,4
]}

机构：

[1] Taichung Vet Gen Hosp, Dept Internal Med, Div Hematol Med Oncol, Taichung 40705, Taiwan

[2] Tunghai Univ, Dept Life Sci, Taichung 40705, Taiwan

[3] Chung Shan Med Univ, Sch Med, Taichung 40705, Taiwan

[4] China Med Univ, Grad Inst Biomed Sci, Taichung 40705, Taiwan

来源：

VACCINES | 2021年 / 9卷 / 12期

关键词：

SARS-CoV-2; immune thrombocytopenia; adenovirus vaccine; ischemic stroke; COVID-19; PRACTICES INTERIM RECOMMENDATION; COVID-19; VACCINE; ADVISORY-COMMITTEE; UNITED-STATES; PURPURA;

D O I：

10.3390/vaccines9121486

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We present a case of immune thrombocytopenia (ITP) induced by the chimpanzee adenovirus-vectored vaccine, without evidence of thrombosis, eight days after vaccine administration. The thrombocytopenia condition improved after administering steroid treatment. This adenovirus vaccine had been reported to induce rare side effects, such as immune thrombotic thrombocytopenia. This case report showed that it could also induce immune thrombocytopenia without the presence of thrombosis. Therefore, we should be cautious of this rare side effect as global vaccine administrations against coronavirus disease increase.

引用

页数：6

共 28 条

[1] MMR vaccine and idiopathic thrombocytopaenic purpura [J].

Black, C ;

Kaye, JA ;

Jick, H .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2003, 55 (01) :107-111

[2] COVID-19 vaccines: The status and perspectives in delivery points of view [J].

Chung, Jee Young ;

Thone, Melissa N. ;

Kwon, Young Jik .

ADVANCED DRUG DELIVERY REVIEWS, 2021, 170 (170) :1-25

[3] The ITP syndrome: pathogenic and clinical diversity [J].

Cines, Douglas B. ;

Bussel, James B. ;

Liebman, Howard A. ;

Prak, Eline T. Luning .

BLOOD, 2009, 113 (26) :6511-6521

[4] Autoimmunity roots of the thrombotic events after COVID-19 vaccination [J].

Elrashdy, Fatma ;

Tambuwala, Murtaza M. ;

Hassan, Sk Sarif ;

Adadi, Parise ;

Seyran, Murat ;

Abd El-Aziz, Tarek Mohamed ;

Rezaei, Nima ;

Lal, Amos ;

Aljabali, Alaa A. A. ;

Kandimalla, Ramesh ;

Bazan, Nicolas G. ;

Azad, Gajendra Kumar ;

Sherchan, Samendra P. ;

Choudhury, Pabitra Pal ;

Serrano-Aroca, Angel ;

Takayama, Kazuo ;

Chauhan, Gaurav ;

Pizzol, Damiano ;

Barh, Debmalya ;

Panda, Pritam Kumar ;

Mishra, Yogendra K. ;

Palu, Giorgio ;

Lundstrom, Kenneth ;

Redwan, Elrashdy M. ;

Uversky, Vladimir N. .

AUTOIMMUNITY REVIEWS, 2021, 20 (11)

[5] Secondary immune thrombocytopenia supposedly attributable to COVID-19 vaccination [J].

Fueyo-Rodriguez, Omar ;

Valente-Acosta, Benjamin ;

Jimenez-Soto, Rodolfo ;

Neme-Yunes, Yvette ;

Ignacio Inclan-Alarcon, Sergio ;

Trejo-Gonzalez, Roxana ;

Angel Garcia-Salcido, Miguel .

BMJ CASE REPORTS, 2021, 14 (05)

[6]

Ganzel C, 2021, ISR MED ASSOC J, V23, P341

[7] Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination [J].

Greinacher, Andreas ;

Thiele, Thomas ;

Warkentin, Theodore E. ;

Weisser, Karin ;

Kyrle, Paul A. ;

Eichinger, Sabine .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (22) :2092-2101

[8] The reporting completeness of a passive safety surveillance system for pandemic (H1N1) 2009 vaccines: A capture-recapture analysis [J].

Huang, Wan-Ting ;

Huang, Wei-I ;

Huang, Yu-Wen ;

Hsu, Chien-Wen ;

Chuang, Jen-Hsiang .

VACCINE, 2012, 30 (12) :2168-2172

[9] Idiopathic Thrombocytopenic Purpura and the Moderna Covid-19 Vaccine [J].

Julian, Jeffrey A. ;

Mathern, Douglas R. ;

Fernando, Dinali .

ANNALS OF EMERGENCY MEDICINE, 2021, 77 (06) :654-656

[10] Performance Evaluation of Different D-Dimer Cutoffs in Bedridden Hospitalized Elderly Patients [J].

Kassim, Nevine A. ;

Farid, Tamer M. ;

Pessar, Shaimaa Abdelmalik ;

Shawkat, Salma A. .

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2017, 23 (08) :998-1004

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