Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain

被引：41
作者：
Fagan, R [1 ]
Swindells, M [1 ]
Overington, J [1 ]
Weir, M [1 ]
机构：
[1] Inpharmat, London W1T 2NU, England
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 04期
关键词：
D O I：
10.1016/S0968-0004(01)01789-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nicastrin, a protein implicated in Alzheimer's disease, has a domain that is found in the aminopeptidase/transferrin receptor superfamily, In nicastrin, this domain might possess catalytic activity (as observed with aminopeptidases) or it could serve merely as a binding domain (with analogy to the transferrin receptors) for the beta -amyloid precursor protein.
引用
收藏
页码：213 / 214
页数：2
相关论文
共 7 条
  • [1] Streptomyces griseus aminopeptidase: X-ray crystallographic structure at 1.75 angstrom resolution
    Greenblatt, HM
    Almog, O
    Maras, B
    SpunginBialik, A
    Barra, D
    Blumberg, S
    Shoham, G
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1997, 265 (05) : 620 - 636
  • [2] GenTHREADER: An efficient and reliable protein fold recognition method for genomic sequences
    Jones, DT
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1999, 287 (04) : 797 - 815
  • [3] Crystal structure of the ectodomain of human transferrin receptor
    Lawrence, CM
    Ray, S
    Babyonyshev, M
    Galluser, R
    Borhani, DW
    Harrison, SC
    [J]. SCIENCE, 1999, 286 (5440) : 779 - 782
  • [4] Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
    Li, YM
    Xu, M
    Lai, MT
    Huang, Q
    Castro, JL
    DiMuzio-Mower, J
    Harrison, T
    Lellis, C
    Nadin, JL
    Neduvelil, JG
    Register, RB
    Sardana, MK
    Shearman, MS
    Smith, AL
    Shi, XP
    Yin, KC
    Shafer, JA
    Gardell, SJ
    [J]. NATURE, 2000, 405 (6787) : 689 - 694
  • [5] Mahadevan D, 1999, PROTEIN SCI, V8, P2546
  • [6] COMPLEMENT GENES C1R AND C1S FEATURE AN INTRONLESS SERINE PROTEASE DOMAIN CLOSELY RELATED TO HAPTOGLOBIN
    TOSI, M
    DUPONCHEL, C
    MEO, T
    COUTURETOSI, E
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1989, 208 (04) : 709 - 714
  • [7] Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
    Yu, G
    Nishimura, M
    Arawaka, S
    Levitan, D
    Zhang, LL
    Tandon, A
    Song, YQ
    Rogaeva, E
    Chen, FS
    Kawaral, T
    Supala, A
    Levesque, L
    Yu, H
    Yang, DS
    Holmes, E
    Millman, P
    Liang, Y
    Zhang, DM
    Xu, DH
    Sato, C
    Rogaev, E
    Smith, M
    Janus, C
    Zhang, YN
    Aebersold, R
    Farrer, L
    Sorbi, S
    Bruni, A
    Fraser, P
    St George-Hyslop, P
    [J]. NATURE, 2000, 407 (6800) : 48 - 54
1