Immune Responses to SARS-CoV-2 Infection and Vaccination in Dialysis Patients and Kidney Transplant Recipients

被引：13

作者：

Affeldt, Patrick ^{[1
,2
,3
]}

Koehler, Felix Carlo ^{[1
,2
,3
,4
,5
]}

Brensing, Karl August ^{[6
]}

Adam, Vivien ^{[1
,2
,3
]}

Burian, Julia ^{[7
]}

Butt, Linus ^{[1
,2
,3
,4
,5
]}

Gies, Martin ^{[8
]}

Grundmann, Franziska ^{[1
,2
,3
]}

Hinrichs, Steffen ^{[1
,2
,3
]}

Johannis, Wibke ^{[9
,10
]}

Kalisch, Nils ^{[1
,2
,3
]}

Meyer-Delpho, Matthias ^{[11
]}

Oehm, Simon ^{[1
,2
,3
]}

Platen, Eva ^{[12
]}

Schoeler, Claudia ^{[8
]}

Heger, Eva ^{[13
,14
]}

Steger, Gertrud ^{[13
,14
]}

Stippel, Dirk ^{[15
]}

Ziegelhoefer, Aileen ^{[13
,14
]}

Benzing, Thomas ^{[1
,2
,3
,4
,5
]}

Klein, Florian ^{[13
,14
]}

Kurschat, Christine ^{[1
,2
,3
,4
,5
]}

Mueller, Roman-Ulrich ^{[1
,2
,3
,4
,5
]}

Di Cristanziano, Veronica ^{[13
,14
]}

机构：

[1] Univ Cologne, Fac Med, Dept Internal Med 2, D-50937 Cologne, Germany

[2] Univ Hosp Cologne, Fac Med, Ctr Mol Med Cologne, D-50937 Cologne, Germany

[3] Univ Cologne, Univ Hosp Cologne, D-50937 Cologne, Germany

[4] Univ Cologne, CECAD, Fac Med, D-50931 Cologne, Germany

[5] Univ Cologne, Univ Hosp Cologne, D-50931 Cologne, Germany

[6] Nierenzentrum Bonn, D-53175 Bonn, Germany

[7] Nieren & Dialysezentrum Rheinbach, D-53359 Rheinbach, Germany

[8] KfH Nierenzentrum Koln Longerich, D-50737 Cologne, Germany

[9] Fac Med, Inst Clin Chem, D-50937 Cologne, Germany

[10] Univ Cologne, Univ Hosp Cologne, D-50937 Cologne, Germany

[11] Dialysezentrum Siegburg, D-53721 Siegburg, Germany

[12] Nierenzentrum Eifel, D-53894 Mechernich, Germany

[13] Fac Med, Inst Virol, D-50935 Cologne, Germany

[14] Univ Cologne, Univ Hosp Cologne, D-50935 Cologne, Germany

[15] Univ Cologne, Univ Hosp Cologne, Fac Med, Dept Gen Visceral Canc & Transplant Surg, D-50937 Cologne, Germany

来源：

MICROORGANISMS | 2022年 / 10卷 / 01期

关键词：

COVID-19; immunosuppression; protection; titer; antibodies; kidney disease; HEMODIALYSIS-PATIENTS; BNT162B2; VACCINE; COVID-19; T-CELL; LONGEVITY; ANTIBODY; DISEASE;

D O I：

10.3390/microorganisms10010004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Dialysis patients and kidney transplant (KTX) recipients suffer from an impaired immune system and show a decreased response to the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination. We performed a retrospective analysis of 1505 serological SARS-CoV-2 measurements obtained from 887 dialysis patients and 86 KTX recipients. The results were separated by patient subgroups (dialysis/KTX) as well as SARS-CoV-2 status. The latter criterion included SARS-CoV-2-naive patients with or without COVID-19 vaccination and convalescent patients receiving a booster shot. Serologies of 27 vaccinated healthy individuals served as the reference group. Vaccine-induced cellular immune response was quantified by an interferon-gamma release assay in 32 KTX recipients. We determined seroconversion rates of 92.6%, 93.4%, and 71.4% in dialysis patients vaccinated with either BNT162b2, mRNA-1273, or AZD1222, respectively. Vaccination-induced anti-SARS-CoV-2 antibody titers were lower in dialysis patients compared to healthy individuals, and vaccination with mRNA-1273 induced higher titers than BNT162b2. The initial seroconversion rate was 39.5% in KTX recipients vaccinated with BNT162b2. A linear regression model identified medication with mycophenolate-mofetil/mycophenolic acid as an independent risk factor for missing seroconversion. Within a cohort of 32 KTX recipients, cellular and humoral immune reactivity to SARS-CoV-2 was detectable in three patients only. Conclusively, vaccine-induced seroconversion rates were similar in dialysis patients compared to healthy individuals but were strongly impaired in KTX recipients. Anti-SARS-CoV-2 IgG titers elicited by double active immunization were significantly lower in both cohorts compared to healthy individuals, and immune responses to vaccination vanished quickly.

引用

页数：14

共 39 条

[1]

Akalin E, 2020, NEW ENGL J MED, V382, P2475, DOI 10.1056/NEJMc2011117

[2] Contributions of humoral and cellular immunity to vaccine-induced protection in humans [J].

Amanna, Ian J. ;

Slifka, Mark K. .

VIROLOGY, 2011, 411 (02) :206-215

[3] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[4] Antibody Response After a Third Dose of the mRNA-1273 SARS-CoV-2 Vaccine in Kidney Transplant Recipients With Minimal Serologic Response to 2 Doses [J].

Benotmane, Ilies ;

Gautier, Gabriela ;

Perrin, Peggy ;

Olagne, Jerome ;

Cognard, Noelle ;

Fafi-Kremer, Samira ;

Caillard, Sophie .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 326 (11) :1063-1065

[5] Low immunization rates among kidney transplant recipients who received 2 doses of the mRNA-1273 SARS-CoV-2 vaccine [J].

Benotmane, Ilies ;

Gautier-Vargas, Gabriela ;

Cognard, Noelle ;

Olagne, Jerome ;

Heibel, FrancOise ;

Braun-Parvez, Laura ;

Martzloff, Jonas ;

Perrin, Peggy ;

Moulin, Bruno ;

Fafi-Kremer, Samira ;

Caillard, Sophie .

KIDNEY INTERNATIONAL, 2021, 99 (06) :1498-1500

[6] Antibody and T Cell Response to SARS-CoV-2 Messenger RNA BNT162b2 Vaccine in Kidney Transplant Recipients and Hemodialysis Patients [J].

Bertrand, Dominique ;

Hamzaoui, Mouad ;

Lemee, Veronique ;

Lamulle, Julie ;

Hanoy, Melanie ;

Laurent, Charlotte ;

Lebourg, Ludivine ;

Etienne, Isabelle ;

Lemoine, Mathilde ;

Le Roy, Frank ;

Nezam, Dorian ;

Plantier, Jean-Christophe ;

Boyer, Olivier ;

Guerrot, Dominique ;

Candon, Sophie .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021, 32 (09) :2148-2153

[7] Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients [J].

Boyarsky, Brian J. ;

Werbel, William A. ;

Avery, Robin K. ;

Tobian, Aaron A. R. ;

Massie, Allan B. ;

Segev, Dorry L. ;

Garonzik-Wang, Jacqueline M. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (21) :2204-2206

[8] Is COVID-19 infection more severe in kidney transplant recipients? [J].

Caillard, Sophie ;

Chavarot, Nathalie ;

Francois, Helene ;

Matignon, Marie ;

Greze, Clarisse ;

Kamar, Nassim ;

Gatault, Philippe ;

Thaunat, Olivier ;

Legris, Tristan ;

Frimat, Luc ;

Westeel, Pierre F. ;

Goutaudier, Valentin ;

Jdidou, Mariam ;

Snanoudj, Renaud ;

Colosio, Charlotte ;

Sicard, Antoine ;

Bertrand, Dominique ;

Mousson, Christiane ;

Bamoulid, Jamal ;

Masset, Christophe ;

Thierry, Antoine ;

Couzi, Lionel ;

Chemouny, Jonathan M. ;

Duveau, Agnes ;

Moal, Valerie ;

Blancho, Gilles ;

Grimbert, Philippe ;

Durrbach, Antoine ;

Moulin, Bruno ;

Anglicheau, Dany ;

Ruch, Yvon ;

Kaeuffer, Charlotte ;

Benotmane, Ilies ;

Solis, Morgane ;

LeMeur, Yannick ;

Hazzan, Marc ;

Danion, Francois .

AMERICAN JOURNAL OF TRANSPLANTATION, 2021, 21 (03) :1295-1303

[9] Longevity of SARS-CoV-2 immune responses in hemodialysis patients and protection against reinfection [J].

Clarke, Candice L. ;

Prendecki, Maria ;

Dhutia, Amrita ;

Gan, Jaslyn ;

Edwards, Claire ;

Prout, Virginia ;

Lightstone, Liz ;

Parker, Eleanor ;

Marchesin, Federica ;

Griffith, Megan ;

Charif, Rawya ;

Pickard, Graham ;

Cox, Alison ;

McClure, Myra ;

Tedder, Richard ;

Randell, Paul ;

Greathead, Louise ;

Guckian, Mary ;

McAdoo, Stephen P. ;

Kelleher, Peter ;

Willicombe, Michelle .

KIDNEY INTERNATIONAL, 2021, 99 (06) :1470-1477

[10] Epidemiology of COVID-19 in an Urban Dialysis Center [J].

Corbett, Richard W. ;

Blakey, Sarah ;

Nitsch, Dorothea ;

Loucaidou, Marina ;

McLean, Adam ;

Duncan, Neill ;

Ashby, Damien R. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020, 31 (08) :1815-1823

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