Three new isopimaric acid diterpenoids from the bark of Cryptomeria japonica and their xanthine oxidase inhibitory activity

被引：2
作者：
Chang, Chi-, I [1 ,2 ]
Chen, Cheng-Chi [3 ]
Wang, Sheng-Yang [4 ,5 ]
Chen, Jih-Jung [6 ,7 ]
Chen, Chiy-Rong [8 ]
Chao, Che-Yi [9 ,10 ]
Kuo, Yueh-Hsiung [11 ,12 ,13 ]
机构：
[1] Natl Pingtung Univ Sci & Technol, Dept Biol Sci & Technol, Pingtung 912, Taiwan
[2] Natl Pingtung Univ Sci & Technol, Res Ctr Act Nat Prod Dev, Pingtung 912, Taiwan
[3] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan
[4] Natl Chung Hsing Univ, Dept Forestry, Taichung 402, Taiwan
[5] Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan
[6] Natl Yang Ming Univ, Sch Pharmaceut Sci, Fac Pharm, Taipei 112, Taiwan
[7] China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan
[8] Natl Taitung Univ, Dept Life Sci, Taitung 950, Taiwan
[9] Asia Univ, Dept Food Nutr & Hlth Biotechnol, Taichung, Taiwan
[10] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung, Taiwan
[11] China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, 91 Hsueh Shih Rd, Taichung 404, Taiwan
[12] Asia Univ, Dept Biotechnol, Taichung 413, Taiwan
[13] China Med Univ, Chinese Med Res Ctr, Taichung 404, Taiwan
来源：
PHYTOCHEMISTRY LETTERS | 2021年 / 46卷
关键词：
Cupressaceae; Cryptomeria japonica; Bark; Isopimarane; ABIETANE-TYPE DITERPENES; JAPANESE CEDAR; CONSTITUENTS; TERPENOIDS; EXTRACTS; QUINONE; OIL;
D O I：
10.1016/j.phytol.2021.09.005
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three new isopimaric acid diterpenoids, 6-oxoisopimaric acid (1), 6 alpha-hydroxyisopimaric acid (2), and isopimara7,9(11),15-trien-18-oic acid (4), together with two known isopimaric acid diterpenoids, isopimaric acid (3), and 8(14),15-isopimaradien-18-oic acid (5), were isolated from the bark of Cryptomeria japonica D. Don. Their structures were determined by analysis of spectroscopic data and comparison with the spectral data of known analogues. At the concentration of 50 mu M, compounds 1-5 inhibited xanthine oxidase activity by 17.3, 16.5, 2.6, 30.5, and 24.5 %, respectively.
引用
收藏
页码：61 / 65
页数：5
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