Target Populations for First-In-Human Embryonic Stem Cell Research in Spinal Cord Injury

被引：90

作者：

Bretzner, Frederic ^{[1
]}

Gilbert, Frederic ^{[5
]}

Baylis, Francoise ^{[2
,3
]}

Brownstone, Robert M. ^{[1
,4
]}

机构：

[1] Dalhousie Univ, Dept Anat & Neurobiol, Halifax, NS B3H 3J5, Canada

[2] Dalhousie Univ, Dept Philosophy, Halifax, NS B3H 3J5, Canada

[3] Dalhousie Univ, Dept Obstet & Gynaecol, Halifax, NS B3H 3J5, Canada

[4] Dalhousie Univ, Dept Surg Neurosurg, Halifax, NS B3H 3J5, Canada

[5] Univ Tasmania, ACES, Hobart, Tas 7005, Australia

来源：

CELL STEM CELL | 2011年 / 8卷 / 05期

基金：

加拿大健康研究院;

关键词：

COMMITTED PROGENITOR CELLS; MULTIPLE-SCLEROSIS; CLINICAL-TRIALS; INFLAMMATORY RESPONSE; DOUBLE-BLIND; THERAPEUTIC MISCONCEPTION; TRANSPLANTATION; MACROPHAGES; DIFFERENTIATION; RECOVERY;

D O I：

10.1016/j.stem.2011.04.012

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Geron recently announced that it had begun enrolling patients in the world's first-in-human clinical trial involving cells derived from human embryonic stem cells (hESCs). This trial raises important questions regarding the future of hESC-based therapies, especially in spinal cord injury (SCI) patients. We address some safety and efficacy concerns with this research, as well as the ethics of fair subject selection. We consider other populations that might be better for this research: chronic complete SCI patients for a safety trial, subacute incomplete SCI patients for an efficacy trial, and perhaps primary progressive multiple sclerosis (MS) patients for a combined safety and efficacy trial.

引用

页码：468 / 475

页数：8

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