Effect of Apomorphine on Non-Motor Symptoms in Parkinson's Disease

被引：1
作者：
Honig, H. [1 ]
Odin, P. [1 ,2 ]
Chaudhuri, K. R. [3 ]
机构：
[1] Klinikum Bremerhaven, Abt Neurol, D-27574 Bremerhaven, Germany
[2] Univ Krankenhaus, Abt Neurol, Lund, Sweden
[3] Kings Coll London, Dept Neurol, NPF Ctr Excellence, London WC2R 2LS, England
来源：
AKTUELLE NEUROLOGIE | 2011年 / 38卷
关键词：
Parkinson; pump; apomorphine; infusion; non-motor; SUBCUTANEOUS APOMORPHINE; DOPAMINERGIC MODULATION; MULTICENTER; PRAMIPEXOLE; LEVODOPA; DEPRESSION; INFUSION; APATHY; STIMULATION; DIAGNOSIS;
D O I：
10.1055/s-0030-1265982
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In Parkinson's disease non-motor symptoms can appear even before the motor symptoms. Additionally to motor fluctuations and dyskinesias, the non-motor symptoms constitute one of the main problems when treating Parkinson's disease. They are also of high relevance for the quality of life. There are indications that a continuous dopaminergic stimulation can improve symptoms such as depression, sleep as well as autonomic disturbances. Treatment with apomorphine infusion subcutaneously or Duodopa (L-dopa/carbidopa) intraduodenally with portable pump systems are well-established regarding management of motor fluctuations and dyskinesias. Regarding effects on non-motor symptoms there are so far only a few studies with limited number of cases available.
引用
收藏
页码：S34 / S38
页数：5
相关论文
共 50 条
[41]   Non-motor fluctuations in Parkinson's disease [J].
Levin, O. S. ;
Smolentseva, I. G. ;
Ivanov, A. K. .
ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA, 2010, 110 (03) :90-96
[42]   THE HETEROGENEITY OF NON-MOTOR SYMPTOMS IN PATIENTS WITH PARKINSON'S DISEASE IN TOMSK REGION [J].
Nikitina, M. A. ;
Zhukova, N. G. ;
Bragina, E. Yu ;
Alifirova, V. M. ;
Zhukova, I. A. ;
Gomboeva, D. E. ;
Brazovskaya, N. G. ;
Izhboldina, O. P. ;
Zhalsanova, I. Zh .
YAKUT MEDICAL JOURNAL, 2019, (03) :65-69
[43]   Slave to the rhythm: Seasonal differences in non-motor symptoms in Parkinson's disease [J].
van Wamelen, Daniel J. ;
Podlewska, Aleksandra M. ;
Leta, Valentina ;
Smilowska, Katarzyna ;
Rizos, Alexandra ;
Martinez-Martin, Pablo ;
Bloem, Bas R. ;
Chaudhuri, K. Ray .
PARKINSONISM & RELATED DISORDERS, 2019, 63 :73-76
[44]   Rotigotine and specific non-motor symptoms of Parkinson's disease: Post hoc analysis of RECOVER [J].
Chaudhuri, K. Ray ;
Martinez-Martin, Pablo ;
Antonini, Angelo ;
Brown, Richard G. ;
Friedman, Joseph H. ;
Onofrj, Marco ;
Surmann, Erwin ;
Ghys, Liesbet ;
Trenkwalder, Claudia .
PARKINSONISM & RELATED DISORDERS, 2013, 19 (07) :660-665
[45]   Gender differences in non-motor symptoms in early, drug na⟨ve Parkinson's disease [J].
Picillo, Marina ;
Amboni, Marianna ;
Erro, Roberto ;
Longo, Katia ;
Vitale, Carmine ;
Moccia, Marcello ;
Pierro, Angela ;
Santangelo, Gabriella ;
De Rosa, Anna ;
De Michele, Giuseppe ;
Santoro, Lucio ;
Orefice, Giuseppe ;
Barone, Paolo ;
Pellecchia, Maria Teresa .
JOURNAL OF NEUROLOGY, 2013, 260 (11) :2849-2855
[46]   Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease [J].
Jiang, Yimiao ;
Qi, Zengxin ;
Zhu, Huixian ;
Shen, Kangli ;
Liu, Ruiqi ;
Fang, Chenxin ;
Lou, Weiwei ;
Jiang, Yifan ;
Yuan, Wangrui ;
Cao, Xin ;
Chen, Liang ;
Zhuang, Qianxing .
NEURAL REGENERATION RESEARCH, 2025, 20 (06) :1628-1643
[47]   Gender effect on non-motor symptoms in Parkinson's disease: are men more at risk? [J].
Nicoletti, A. ;
Vasta, R. ;
Mostile, G. ;
Nicoletti, G. ;
Arabia, G. ;
Iliceto, G. ;
Lamberti, P. ;
Marconi, R. ;
Morgante, L. ;
Barone, P. ;
Quattrone, A. ;
Zappia, M. .
PARKINSONISM & RELATED DISORDERS, 2017, 35 :69-74
[48]   Motor and non-motor symptoms, drugs, and their mode of action in Parkinson's disease (PD): a review [J].
Saini, Nancy ;
Singh, Neetu ;
Kaur, Navneet ;
Garg, Sonali ;
Kaur, Manvinder ;
Kumar, Asim ;
Verma, Meenakshi ;
Singh, Kishanpal ;
Sohal, Harvinder Singh .
MEDICINAL CHEMISTRY RESEARCH, 2024, 33 (04) :580-599
[49]   Functional imaging of non-motor signs in Parkinson's disease [J].
Ballanger, Benedicte ;
Poisson, Alice ;
Broussolle, Emmanuel ;
Thobois, Stephane .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2012, 315 (1-2) :9-14
[50]   Non-Motor Correlates of Smoking Habits in de Novo Parkinson's Disease [J].
Moccia, Marcello ;
Mollenhauer, Brit ;
Erro, Roberto ;
Picillo, Marina ;
Palladino, Raffaele ;
Barone, Paolo .
JOURNAL OF PARKINSONS DISEASE, 2015, 5 (04) :913-924
12345