Getting the picture: The coming of age of imaging MS

被引：54

作者：

Heeren, Ron M. A. ^{[1
]}

机构：

[1] FOM AMOLF, NL-1098 XG Amsterdam, Netherlands

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 2015年 / 377卷

关键词：

Mass spectrometry imaging; MALDI; Desorption and ionization; SIMS; Top-down imaging; High spatial resolution; ULTRAVIOLET-LASER DESORPTION; IONIZATION MASS-SPECTROMETRY; HIGH-SPATIAL-RESOLUTION; MULTIPLY-CHARGED IONS; SAMPLE PREPARATION; MATRIX; PROTEIN; ACID; BOMBARDMENT; SENSITIVITY;

D O I：

10.1016/j.ijms.2014.04.021

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

This retrospective on imaging mass spectrometry describes the coming of age of an approach that has matured from an innovative technological development to a broadly applied analytical tool. A look back in time reveals how the breadth of imaging mass spectrometry has expanded from a purely (semiconductor) surface physics field to its recent impact on biomedicine, nanotechnology and culture. The impact of historical milestones in desorption and ionization technologies on the progress in modern multimodal molecular imaging technologies is described and discussed. A concise picture is sketched of the roadmap that contains the key advances in imaging mass spectrometry methods and technologies. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：672 / 680

页数：9

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