Getting the picture: The coming of age of imaging MS

被引:54
作者
Heeren, Ron M. A. [1 ]
机构
[1] FOM AMOLF, NL-1098 XG Amsterdam, Netherlands
关键词
Mass spectrometry imaging; MALDI; Desorption and ionization; SIMS; Top-down imaging; High spatial resolution; ULTRAVIOLET-LASER DESORPTION; IONIZATION MASS-SPECTROMETRY; HIGH-SPATIAL-RESOLUTION; MULTIPLY-CHARGED IONS; SAMPLE PREPARATION; MATRIX; PROTEIN; ACID; BOMBARDMENT; SENSITIVITY;
D O I
10.1016/j.ijms.2014.04.021
中图分类号
O64 [物理化学(理论化学)、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号
070203 ; 070304 ; 081704 ; 1406 ;
摘要
This retrospective on imaging mass spectrometry describes the coming of age of an approach that has matured from an innovative technological development to a broadly applied analytical tool. A look back in time reveals how the breadth of imaging mass spectrometry has expanded from a purely (semiconductor) surface physics field to its recent impact on biomedicine, nanotechnology and culture. The impact of historical milestones in desorption and ionization technologies on the progress in modern multimodal molecular imaging technologies is described and discussed. A concise picture is sketched of the roadmap that contains the key advances in imaging mass spectrometry methods and technologies. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:672 / 680
页数:9
相关论文
共 84 条
  • [61] SHIMMA S, 2006, J MASS SPECTROM SOC, V54, P2006
  • [62] C60 Secondary Ion Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
    Smith, Donald F.
    Robinson, Errol W.
    Tolmachev, Aleksey V.
    Heeren, Ron M. A.
    Pasa-Tolic, Ljiljana
    [J]. ANALYTICAL CHEMISTRY, 2011, 83 (24) : 9552 - 9556
  • [63] MALDI Mass Spectrometry Imaging in Microscope Mode with Infrared Lasers: Bypassing the Diffraction Limits
    Soltwisch, Jens
    Goeritz, Guido
    Jungmann, Julia H.
    Kiss, Andras
    Smith, Donald F.
    Ellis, Shane R.
    Heeren, Ron M. A.
    [J]. ANALYTICAL CHEMISTRY, 2014, 86 (01) : 321 - 325
  • [64] Scanning microprobe matrix-assisted laser desorption ionization (SMALDI) mass spectrometry: Instrumentation for sub-micrometer resolved LDI and MALDI surface analysis
    Spengler, B
    Hubert, M
    [J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2002, 13 (06) : 735 - 748
  • [65] ULTRAVIOLET-LASER DESORPTION IONIZATION MASS-SPECTROMETRY OF PROTEINS ABOVE 100000 DALTONS BY PULSED ION EXTRACTION TIME-OF-FLIGHT ANALYSIS
    SPENGLER, B
    COTTER, RJ
    [J]. ANALYTICAL CHEMISTRY, 1990, 62 (08) : 793 - 796
  • [66] STEPHENS WE, 1946, PHYS REV, V69, P691
  • [67] Application of focused ion beam lift-out specimen preparation to TEM, SEM, STEM, AES and SIMS analysis
    Stevie, FA
    Vartuli, CB
    Giannuzzi, LA
    Shofner, TL
    Brown, SR
    Rossie, B
    Hillion, F
    Mills, RH
    Antonell, M
    Irwin, RB
    Purcell, BM
    [J]. SURFACE AND INTERFACE ANALYSIS, 2001, 31 (05) : 345 - 351
  • [68] Automated mass spectrometry imaging with a matrix-assisted laser desorption ionization time-of-flight instrument
    Stoeckli, M
    Farmer, TB
    Caprioli, RM
    [J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1999, 10 (01) : 67 - 71
  • [69] 2,5-DIHYDROXYBENZOIC ACID - A NEW MATRIX FOR LASER DESORPTION IONIZATION MASS-SPECTROMETRY
    STRUPAT, K
    KARAS, M
    HILLENKAMP, F
    [J]. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, 1991, 111 : 89 - 102
  • [70] High-Reactivity Matrices Increase the Sensitivity of Matrix Enhanced Secondary Ion Mass Spectrometry
    Svara, Fabian N.
    Kiss, Andras
    Jaskolla, Thorsten W.
    Karas, Michael
    Heeren, Ron M. A.
    [J]. ANALYTICAL CHEMISTRY, 2011, 83 (21) : 8308 - 8313