Anti-inflammatory activities of tormentic acid from suspension cells of Eriobotrya Japonica ex vivo and in vivo

被引：61

作者：

Chang, Chwen-Tzuei ^{[2
]}

Huang, Shyh-Shyun ^{[3
]}

Lin, Shiang-Shiou ^{[3
]}

Amagaya, Sakae ^{[4
]}

Ho, Hui-Ya ^{[5
]}

Hou, Wen-Chi ^{[6
]}

Shie, Pei-Hsin ^{[3
]}

Wu, Jin-Bin ^{[1
]}

Huang, Guan-Jhong ^{[3
]}

机构：

[1] China Med Univ, Grad Inst Pharmaceut Chem, Taichung, Taiwan

[2] China Med Univ Hosp, Dept Internal Med, Div Endocrinol & Metab, Taichung, Taiwan

[3] China Med Univ, Coll Pharm, Sch Chinese Pharmaceut Sci & Chinese Med Resource, Taichung 404, Taiwan

[4] Nihon Pharmaceut Univ, Dept Kampo Pharmaceut Sci, Saitama, Japan

[5] Jen Li Biotech Co Ltd, Taiping City 411, Taichung, Taiwan

[6] Taipei Med Univ, Grad Inst Pharmacognosy, Taipei, Taiwan

来源：

FOOD CHEMISTRY | 2011年 / 127卷 / 03期

关键词：

Tormentic acid; Anti-inflammation; TBARS; NO; TNF-alpha; LIPID-PEROXIDATION; TRITERPENE ACIDS; OLEANOLIC ACID; STRAWBERRY; INDUCTION;

D O I：

10.1016/j.foodchem.2011.01.114

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Anti-inflammatory effects of tormentic acid (TA) were investigated ex vivo and in vivo. TA decreased the paw edema at the 4th and 5th hour after lambda-carrageenin (Carr) administration, and increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the liver tissue. TA also significantly attenuated the thiobarbituric acid reactive substances (TBARS) level in the edematous paw at the 5th hour after Carr injection. TA decreased the nitric oxide (NO) levels on the serum level and diminished the serum tumour necrosis factor (TNF-alpha) at the 5th hour after Carr injection. Western blotting revealed that the TA decreased Carr-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions. As per results, the anti-inflammatory mechanisms of TA might be correlated to the decrease in the level of TBARS, iNOS, and COX-2 in the edema paw via increasing the activities of CAT, SOD, and GPx in the liver. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1131 / 1137

页数：7

共 25 条

[1]

Aebi H, 1984, Methods Enzymol, V105, P121

[2] Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects [J].

Banno, N ;

Akihisa, T ;

Tokuda, H ;

Yasukawa, K ;

Higashihara, H ;

Ukiya, M ;

Watanabe, K ;

Kimura, Y ;

Hasegawa, J ;

Nishino, H .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2004, 68 (01) :85-90

[3]

CHANG HY, 2009, EVID-BASED COMPL ALT, DOI DOI 10.1093/ECAM/NEP027

[4] Inhibitory response of Raphanus sativus on lipid peroxidation in albino rats [J].

Chaturvedi, P. .

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2008, 5 (01) :55-59

[5] Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase [J].

Chen, J ;

Liu, J ;

Zhang, LY ;

Wu, GZ ;

Hua, WY ;

Wu, XM ;

Sun, HB .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (11) :2915-2919

[6]

DAWSON J, 1991, INT J TISSUE REACT, V13, P171

[7]

FLOHE L, 1984, METHOD ENZYMOL, V105, P93

[8] Tormentic acid reduces vascular smooth muscle cell proliferation and survival [J].

Fogo, Anelize S. ;

Antonioli, Eliane ;

Calixto, Joao B. ;

Campos, Alexandre H. .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2009, 615 (1-3) :50-54

[9] Melatonin is a scavenger of peroxynitrite [J].

Gilad, E ;

Cuzzocrea, S ;

Zingarelli, B ;

Salzman, AL ;

Szabo, C .

LIFE SCIENCES, 1997, 60 (10) :PL169-PL174

[10] Triterpene phytoalexins from strawberry fruit [J].

Hirai, N ;

Sugie, M ;

Wada, M ;

Lahlou, EH ;

Kamo, T ;

Yoshida, R ;

Tsuda, M ;

Ohigashi, H .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2000, 64 (08) :1707-1712

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