Pulmonary hypertension in end-stage renal disease

被引:17
作者
Devasahayam, Joe [1 ]
Oliver, Tony [2 ]
Joseph, Valentina [3 ]
Nambiar, Sudheer [4 ]
Gunasekaran, Kulothungan [5 ]
机构
[1] Univ South Dakota, Div Pulm Crit Care Med, Sanford Sch Med, E Clark St, Vermillion, SD 57069 USA
[2] Univ South Dakota, Dept Internal Med, Sanford Sch Med, E Clark St, Vermillion, SD 57069 USA
[3] Univ South Dakota, Div Neurol, Sanford Sch Med, E Clark St, Vermillion, SD 57069 USA
[4] Canc Treatment Ctr Amer, Div Pulm Crit Care Med, 10109 E 79th St, Tulsa, OK 74133 USA
[5] Yale New Haven Hlth Bridgeport Hosp, Div Pulm Crit Care Med, 267 Grant St, Bridgeport, CT 06610 USA
关键词
End stage; Renal; Disease; Pulmonary; Hypertension; CHRONIC DIALYSIS PATIENTS; OBSTRUCTIVE SLEEP-APNEA; PERITONEAL-DIALYSIS; CALCIFICATION; HEMODIALYSIS; PREVALENCE; DIAGNOSIS; FAILURE; FLOW;
D O I
10.1016/j.rmed.2020.105905
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Pulmonary hypertension associated with end-stage renal disease (ESRD) is an important yet under-recognized condition and can lead to life-threatening complications. The pathogenesis of pulmonary hypertension is peculiar in ESRD, and understanding it is important to recognize such patients at the earliest and commence appropriate treatment. Many studies have discovered the prevalence of pulmonary hypertension to be up to 80% in ESRD and have been associated with increased mortality. WHO has classified pulmonary hypertension in renal failure to be in group 5, a group defined by unclear multifactorial etiologies. Moreover, there is an improvement with renal transplant and closure of AV fistula, thus confirming the contribution from these. The pharmacological management of pulmonary hypertension in this unique population is not very different from other etiologies. However, one should understand that pulmonary hypertension as such, could be multifactorial, and other secondary causes of pulmonary hypertension should also be recognized and treated accordingly. In this article, we will discuss the concept of pulmonary hypertension in ESRD in detail and the options of treatment.
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页数:5
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