The Wilms' tumour suppressor protein, WT1, undergoes CRM1-independent nucleocytoplasmic shuttling

被引：31
作者：
Vajjhala, PR
Macmillan, E
Gonda, T
Little, M [1 ]
机构：
[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia
[2] Hanson Inst, Adelaide, SA 5000, Australia
[3] Child Hlth Res Inst, Adelaide, SA 5006, Australia
来源：
FEBS LETTERS | 2003年 / 554卷 / 1-2期
基金：
英国医学研究理事会;
关键词：
WT1; nucleocytoplasmic shuttling;
D O I：
10.1016/S0014-5793(03)01144-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Wilms' tumour suppressor gene (WT1) encodes a zinc finger-containing nuclear protein essential for kidney and urogenital development. Initially considered a transcription factor, there is mounting evidence that WT1 has a role in post-transcriptional processing. Using the interspecies heterokaryon assay, we have demonstrated that WT1 can undergo nucleocytoplasmic shuttling. We have also mapped the region responsible for nuclear export to residues 182-324. Our data add further complexity to the role of WT1 in trancriptional and post-transcriptional regulation. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
引用
收藏
页码：143 / 148
页数：6
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