JmjC:: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2β

被引：193

作者：

Clissold, PM ^{[1
]}

Ponting, CP ^{[1
]}

机构：

[1] Univ Oxford, Dept Human Anat & Genet, MRC Funct Genet Unit, Oxford OX1 3QX, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 01期

关键词：

D O I：

10.1016/S0968-0004(00)01700-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

On the basis of significant sequence similarity, we have identified JmjC domains in more than 100 eukaryotic and bacterial sequences,These include human hairless, mutated in individuals with alopecia universalis, retinoblastoma-binding protein 2 and several putative chromatin-associated proteins. JmjC domains are predicted to be metalloenzymes that adopt the cupin fold, and are candidates for enzymes that regulate chromatin remodelling.

引用

页码：7 / 9

页数：3

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