JmjC:: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2β

被引：191
作者：
Clissold, PM [1 ]
Ponting, CP [1 ]
机构：
[1] Univ Oxford, Dept Human Anat & Genet, MRC Funct Genet Unit, Oxford OX1 3QX, England
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 01期
关键词：
D O I：
10.1016/S0968-0004(00)01700-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
On the basis of significant sequence similarity, we have identified JmjC domains in more than 100 eukaryotic and bacterial sequences,These include human hairless, mutated in individuals with alopecia universalis, retinoblastoma-binding protein 2 and several putative chromatin-associated proteins. JmjC domains are predicted to be metalloenzymes that adopt the cupin fold, and are candidates for enzymes that regulate chromatin remodelling.
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页码：7 / 9
页数：3
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