Toward Clarity in Clinical Vitamin D Status Assessment: 25(OH)D Assay Standardization

被引：51

作者：

Binkley, Neil ^{[1
]}

Carter, Graham D. ^{[2
]}

机构：

[1] Univ Wisconsin, Osteoporosis Clin Res Program, 2870 Univ Ave, Madison, WI 53705 USA

[2] Imperial Coll Healthcare NHS Trust, Charing Cross Hosp, Vitamin External Qual Assessment Scheme DEQAS D, Fulham Palace Rd, London W6 8RF, England

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2017年 / 46卷 / 04期

关键词：

25-Hydroxyvitamin D; Vitamin D External Quality Assessment Scheme; National Institute of Standards and Technology; Office of Dietary Supplements; Standardization/harmonization; Vitamin D Standardization Program; Vitamin D; TANDEM MASS-SPECTROMETRY; 25-HYDROXYVITAMIN D DATA; D DEFICIENCY; SERUM CONCENTRATIONS; LABORATORY MEDICINE; PROGRAM PROTOCOLS; CHROMATOGRAPHY; D-3; TRACEABILITY; POPULATION;

D O I：

10.1016/j.ecl.2017.07.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Widespread variation in 25-hydroxyvitamin D (25(OH)D) assays continues to compromise efforts to develop clinical and public health guidelines regarding vitamin D status. The Vitamin D Standardization Program helps alleviate this problem. Reference measurement procedures and standard reference materials have been developed to allow current, prospective, and retrospective standardization of 25(OH)D results. Despite advances in 25(OH)D measurement, substantial variability in clinical laboratory 25(OH)D measurement persists. Existing guidelines have not used standardized data and, as a result, it seems unlikely that consensus regarding definitions of vitamin D deficiency, inadequacy, sufficiency, and excess will soon be reached. Until evidence-based consensus is reached, a reasonable clinical approach is advocated.

引用

页码：885 / +

页数：16

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