What's new in perioperative nutritional support?

被引:27
作者
Awad, Sherif [1 ]
Lobo, Dileep N. [1 ]
机构
[1] Univ Nottingham Hosp, Queens Med Ctr, Div Gastrointestinal Surg, Nottingham Digest Dis Ctr,NIHR Biomed Res Unit, Nottingham NG7 2UH, England
关键词
malnourished; nutrition; outcomes; perioperative; surgery; PREOPERATIVE ORAL CARBOHYDRATE; RANDOMIZED CLINICAL-TRIAL; MAJOR ABDOMINAL-SURGERY; CRITICALLY-ILL PATIENTS; ENTERAL NUTRITION; PARENTERAL-NUTRITION; COLORECTAL SURGERY; INSULIN-RESISTANCE; ENHANCED-RECOVERY; WEIGHT-LOSS;
D O I
10.1097/ACO.0b013e328345865e
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Purpose of review To highlight recent developments in the field of perioperative nutritional support by reviewing clinically pertinent English language articles from October 2008 to December 2010, that examined the effects of malnutrition on surgical outcomes, optimizing metabolic function and nutritional status preoperatively and postoperatively. Recent findings Recognition of patients with or at risk of malnutrition remains poor despite the availability of numerous clinical aids and clear evidence of the adverse effects of poor nutritional status on postoperative clinical outcomes. Unfortunately, poor design and significant heterogeneity remain amongst many studies of nutritional interventions in surgical patients. Patients undergoing elective surgery should be managed within a multimodal pathway that includes evidence-based interventions to optimize nutritional status perioperatively. The aforementioned should include screening patients to identify those at high nutritional risk, perioperative immuno-nutrition, minimizing 'metabolic stress' and insulin resistance by preoperative conditioning with carbohydrate-based drinks, glutamine supplementation, minimal access surgery and enhanced recovery protocols. Finally gut-specific nutrients and prokinetics should be utilized to improve enteral feed tolerance thereby permitting early enteral feeding. Summary An evidence-based multimodal pathway that includes interventions to optimize nutritional status may improve outcomes following elective surgery.
引用
收藏
页码:339 / 348
页数:10
相关论文
共 78 条
[1]  
Ahmed T, 2010, CLIN INTERV AGING, V5, P207
[2]   Early enteral nutrition within 24h of colorectal surgery versus later commencement of feeding for postoperative complications [J].
Andersen, H. K. ;
Lewis, S. J. ;
Thomas, S. .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2006, (04)
[3]  
[Anonymous], 2006, NUTR SUPP AD OR NUTR
[4]   Effect on immune indices of preoperative intravenous glutamine dipeptide supplementation in malnourished abdominal surgery patients in the preoperative and postoperative periods [J].
Asprer, Jonathan M. ;
Llido, Luisito O. ;
Sinamban, Reynaldo ;
Schlotzer, Ewald ;
Kulkarni, Hrishikesh .
NUTRITION, 2009, 25 (09) :920-925
[5]   Symposium 4: Hot topics in parenteral nutrition Current evidence and ongoing trials on the use of glutamine in critically-ill patients and patients undergoing surgery [J].
Avenell, Alison .
PROCEEDINGS OF THE NUTRITION SOCIETY, 2009, 68 (03) :261-268
[6]  
Awad S, 2011, CLIN NUTR
[7]   The effects of fasting and refeeding with a 'metabolic preconditioning' drink on substrate reserves and mononuclear cell mitochondrial function [J].
Awad, Sherif ;
Stephenson, Mary C. ;
Placidi, Elisa ;
Marciani, Luca ;
Constantin-Teodosiu, Dumitru ;
Gowland, Penny A. ;
Spiller, Robin C. ;
Fearon, Kenneth C. H. ;
Morris, Peter G. ;
Macdonald, Ian A. ;
Lobo, Dileep N. .
CLINICAL NUTRITION, 2010, 29 (04) :538-544
[8]   Cellular Mechanisms Underlying the Protective Effects of Preoperative Feeding A Randomized Study Investigating Muscle and Liver Glycogen Content, Mitochondrial Function, Gene and Protein Expression [J].
Awad, Sherif ;
Constantin-Teodosiu, Dumitru ;
Constantin, Despina ;
Rowlands, Brian J. ;
Fearon, Kenneth C. H. ;
Macdonald, Ian A. ;
Lobo, Dileep N. .
ANNALS OF SURGERY, 2010, 252 (02) :247-253
[9]   Knowledge and attitudes of surgical trainees towards nutritional support: Food for thought [J].
Awad, Sherif ;
Herrod, Philip J. J. ;
Forbes, Ewan ;
Lobo, Dileep N. .
CLINICAL NUTRITION, 2010, 29 (02) :243-248
[10]   Short-term starvation and mitochondrial dysfunction - A possible mechanism leading to postoperative insulin resistance [J].
Awad, Sherif ;
Constantin-Teodosiu, Dumitru ;
Macdonald, Ian A. ;
Lobo, Dileep N. .
CLINICAL NUTRITION, 2009, 28 (05) :497-509