PREPARATION OF (2R,4S)/(2S,4S)-4-HYDROXYPIPECOLINIC ACID DERIVATIVES FROM L-(-)-MALIC ACID

被引：0

作者：

Yin, Shugiang ^{[1
]}

Taneda, Hiroshi ^{[1
]}

Li, Bozhi ^{[1
]}

Zhou, Dejun ^{[1
]}

Minato, Daishiro ^{[1
]}

Sugimoto, Kenji ^{[1
]}

Matsuya, Yuji ^{[1
]}

机构：

[1] Toyama Univ, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan

来源：

HETEROCYCLES | 2015年 / 90卷 / 02期

关键词：

4-Hydroxypipecolinic Acid; (-)-Malic Acid; CCK-B ANTAGONISTS; ASYMMETRIC-SYNTHESIS; RAPAMYCIN AY-22,989; PIPECOLIC ACID; AMINO-ACID; STEREOSELECTIVE-SYNTHESIS; IN-VITRO; SUBSTITUTION; CHEMISTRY; RECEPTOR;

D O I：

10.3987/COM-14-S(K)52

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetically important 4-hydroxypipecolinic acid derivatives were efficiently prepared from commercially available L-(-)-malic acid. The stereochemistries of the derivatives synthesized by our method were determined by coupling constant analyses with key methine protons on C-2 and C-4.

引用

页码：928 / 938

页数：11

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