Comparative Molecular Life History of Spontaneous Canine and Human Gliomas

被引：64

作者：

Amin, Samirkumar B. ^{[1
]}

Anderson, Kevin J. ^{[1
]}

Boudreau, C. Elizabeth ^{[2
]}

Martinez-Ledesma, Emmanuel ^{[3
,4
]}

Kocakavuk, Emre ^{[1
,5
,6
]}

Johnson, Kevin C. ^{[1
]}

Barthel, Floris P. ^{[1
]}

Varn, Frederick S. ^{[1
]}

Kassab, Cynthia ^{[7
]}

Ling, Xiaoyang ^{[7
]}

Kim, Hoon ^{[1
]}

Barter, Mary ^{[8
]}

Lau, Ching C. ^{[1
,9
,10
]}

Ngan, Chew Yee ^{[1
]}

Chapman, Margaret ^{[1
]}

Koehler, Jennifer W. ^{[11
]}

Long, James P. ^{[7
,12
]}

Miller, Andrew D. ^{[13
]}

Miller, C. Ryan ^{[14
,15
,16
,17
,27
,28
]}

Porter, Brian F. ^{[18
]}

Rissi, Daniel R. ^{[19
,20
]}

Mazcko, Christina ^{[21
]}

LeBlanc, Amy K. ^{[21
]}

Dickinson, Peter J. ^{[22
]}

Packer, Rebecca A. ^{[23
]}

Taylor, Amanda R. ^{[24
,26
]}

Rossmeisl, John H., Jr. ^{[25
]}

Woolard, Kevin D. ^{[22
]}

Heimberger, Amy B. ^{[7
]}

Levine, Jonathan M. ^{[2
]}

Verhaak, Roel G. W. ^{[1
]}

机构：

[1] Jackson Lab Genom Med, Farmington, CT 06032 USA

[2] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Small Anim Clin Sci, College Stn, TX 77843 USA

[3] Tecnol Monterrey, Escuela Med & Ciencias Salud, Ave Morones Prieto 3000, Monterrey 64710, Nuevo Leon, Mexico

[4] Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Houston, TX 77030 USA

[5] German Canc Consortium DKTK, West German Canc Ctr WTZ, DKFZ Div Translat Neurooncol, Partner Site, Essen, Germany

[6] Univ Hosp Essen, Dept Neurosurg, Essen, Germany

[7] Univ Texas MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA

[8] Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA

[9] Connecticut Childrens Med Ctr, Hartford, CT 06106 USA

[10] Univ Connecticut, Sch Med, Farmington, CT 06032 USA

[11] Auburn Univ, Coll Vet Med, Dept Pathobiol, Auburn, AL 36849 USA

[12] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA

[13] Cornell Univ, Coll Vet Med, Sect Anat Pathol, Dept Biomed Sci, Ithaca, NY 14853 USA

[14] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Dept Pathol & Lab Med, Chapel Hill, NC 27515 USA

[15] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Dept Neurol, Chapel Hill, NC 27515 USA

[16] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Dept Pharmacol, Chapel Hill, NC 27515 USA

[17] Univ N Carolina, Sch Med, Neurosci Ctr, Chapel Hill, NC 27515 USA

[18] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Pathobiol, College Stn, TX USA

[19] Univ Georgia, Coll Vet Med, Dept Pathol, Athens, GA 30602 USA

[20] Univ Georgia, Coll Vet Med, Athens Vet Diagnost Lab, Athens, GA USA

[21] NCI, Comparat Oncol Program, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[22] Univ Calif Davis, Sch Vet Med, Dept Surg & Radiol Sci, Davis, CA USA

[23] Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Clin Sci, Ft Collins, CO 80523 USA

[24] Auburn Univ, Coll Vet Med, Auburn, AL 36849 USA

[25] VA MD Coll Vet Med, Blacksburg, VA USA

[26] MedVet Med & Canc Ctr Pets, Columbus, OH USA

[27] Univ Alabama Birmingham, Dept Pathol, Div Neuropathol, Birmingham, AL 35294 USA

[28] Univ Alabama Birmingham, ONeal Comprehens Canc Ctr, Birmingham, AL USA

来源：

CANCER CELL | 2020年 / 37卷 / 02期

基金：

美国国家卫生研究院;

关键词：

CENTRAL-NERVOUS-SYSTEM; CHROMOSOMAL INSTABILITY; CANCER; EVOLUTION; GENOME; LANDSCAPE; GENES; GRADE; DOGS; CLASSIFICATION;

D O I：

10.1016/j.ccell.2020.01.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sporadic gliomas in companion dogs provide a window on the interaction between tumorigenic mechanisms and host environment. We compared the molecular profiles of canine gliomas with those of human pediatric and adult gliomas to characterize evolutionarily conserved mammalian mutational processes in gliomagenesis. Employing whole-genome, exome, transcriptome, and methylation sequencing of 83 canine gliomas, we found alterations shared between canine and human gliomas such as the receptor tyrosine kinases, TP53 and cell-cycle pathways, and IDH1 R132. Canine gliomas showed high similarity with human pediatric gliomas per robust aneuploidy, mutational rates, relative timing of mutations, and DNA-methylation patterns. Our cross-species comparative genomic analysis provides unique insights into glioma etiology and the chronology of glioma-causing somatic alterations.

引用

页码：243 / +

页数：22

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