Rapid racemization of chiral non-racemic sec-alcohols catalyzed by (η5-C5(CH3)5)Ru complexes bearing tertiary phosphine-primary amine chelate ligands

被引：61
作者：
Ito, M
Osaku, A
Kitahara, S
Hirakawa, M
Kariya, T
机构：
[1] Tokyo Inst Technol, Grad Sch Sci & Engn, Dept Appl Chem, Meguro Ku, Tokyo 1528552, Japan
[2] Tokyo Inst Technol, Frontier Collaborat Res Ctr, Meguro Ku, Tokyo 1528552, Japan
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 40期
关键词：
D O I：
10.1016/j.tetlet.2003.08.005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A ternary catalyst system of Cp*RuCl(cod)-2-diphenylphosphinoethylamine-KOt-Bu (Cp* = eta(5)-C-5(CH3)(5), cod = 1,5-cyclooctadiene) causes rapid racemization of chiral non-racemic sec-alcohols, which results from the reversible hydrogen transfer between sec-alcohols and ketones. Both tertiary phosphine and primary amine functionalities in the ligand are responsible for the high rate. (C) 2003 Elsevier Ltd. All rights reserved.
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页码：7521 / 7523
页数：3
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