Prenatal stress and developmental programming of human health and disease risk: concepts and integration of empirical findings
被引:177
作者:
Entringer, Sonja
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Univ Calif Irvine, UC Irvine Dev Hlth & Dis Res Program, Dept Psychiat & Human Behav, Sch Med,Gillespie Neurosci Res Facil 3117, Irvine, CA 92697 USAUniv Calif Irvine, UC Irvine Dev Hlth & Dis Res Program, Dept Psychiat & Human Behav, Sch Med,Gillespie Neurosci Res Facil 3117, Irvine, CA 92697 USA
Entringer, Sonja
[1
]
Buss, Claudia
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机构:
Univ Calif Irvine, UC Irvine Dev Hlth & Dis Res Program, Dept Psychiat & Human Behav, Sch Med,Gillespie Neurosci Res Facil 3117, Irvine, CA 92697 USAUniv Calif Irvine, UC Irvine Dev Hlth & Dis Res Program, Dept Psychiat & Human Behav, Sch Med,Gillespie Neurosci Res Facil 3117, Irvine, CA 92697 USA
Buss, Claudia
[1
]
Wadhwa, Pathik D.
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机构:
Univ Calif Irvine, UC Irvine Dev Hlth & Dis Res Program, Dept Psychiat & Human Behav, Sch Med,Gillespie Neurosci Res Facil 3117, Irvine, CA 92697 USA
Univ Calif Irvine, Sch Med, Dept Obstet & Gynecol, Irvine, CA 92697 USA
Univ Calif Irvine, Sch Med, Dept Pediat, Irvine, CA 92697 USA
Univ Calif Irvine, Sch Med, Dept Epidemiol, Irvine, CA 92697 USAUniv Calif Irvine, UC Irvine Dev Hlth & Dis Res Program, Dept Psychiat & Human Behav, Sch Med,Gillespie Neurosci Res Facil 3117, Irvine, CA 92697 USA
Wadhwa, Pathik D.
[1
,2
,3
,4
]
机构:
[1] Univ Calif Irvine, UC Irvine Dev Hlth & Dis Res Program, Dept Psychiat & Human Behav, Sch Med,Gillespie Neurosci Res Facil 3117, Irvine, CA 92697 USA
[2] Univ Calif Irvine, Sch Med, Dept Obstet & Gynecol, Irvine, CA 92697 USA
[3] Univ Calif Irvine, Sch Med, Dept Pediat, Irvine, CA 92697 USA
[4] Univ Calif Irvine, Sch Med, Dept Epidemiol, Irvine, CA 92697 USA
Purpose of review The concept of the developmental origins of health and disease susceptibility is rapidly attracting interest and gaining prominence as a complementary approach to understanding the causation of many complex common disorders that confer a major burden of disease; however several important issues and questions remain to be addressed, particularly in the context of humans. Recent findings In this review we enunciate some of these questions and issues, review empirical evidence primarily from our own recent studies on prenatal stress and stress biology, and discuss putative maternal-placental-fetal endocrine and immune/inflammatory candidate mechanisms that may underlie and mediate short-term and long-term effects of prenatal stress on the developing human embryo and fetus, with a specific focus on body composition, metabolic function, and obesity risk. Summary The implications for research and clinical practice are discussed with a summary of recent advances in noninvasive methods to characterize fetal, newborn, infant, and child developmental and health-related processes that, when coupled with available state-of-the-art statistical modeling approaches for longitudinal, repeated measures time series analysis, now afford unprecedented opportunities to explore and uncover the developmental origins of human health and disease.
机构:Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
Bispham, J
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Gopalakrishnan, GS
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机构:Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
Gopalakrishnan, GS
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Dandrea, J
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机构:Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
Dandrea, J
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Wilson, V
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机构:Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
Wilson, V
;
Budge, H
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机构:Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
Budge, H
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Keisler, DH
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机构:Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
Keisler, DH
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Pipkin, FB
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机构:Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
Pipkin, FB
;
Stephenson, T
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机构:Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
Stephenson, T
;
Symonds, ME
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, EnglandUniv Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
机构:
Univ So Calif, Childrens Hosp Los Angeles, Neurosci Program, Saban Res Inst, Los Angeles, CA 90027 USA
Univ Lille 2, INSERM, U837, Jean Pierre Aubert Res Ctr, Lille, FranceUniv So Calif, Childrens Hosp Los Angeles, Neurosci Program, Saban Res Inst, Los Angeles, CA 90027 USA
机构:
Univ Calif Irvine, Dept Psychiat & Human Behav, Orange, CA 92868 USAUniv Calif Irvine, Dept Psychiat & Human Behav, Orange, CA 92868 USA
Buss, Claudia
;
Davis, Elysia Poggi
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机构:
Univ Calif Irvine, Dept Psychiat & Human Behav, Orange, CA 92868 USA
Univ Calif Irvine, Dept Pediat, Irvine, CA 92697 USAUniv Calif Irvine, Dept Psychiat & Human Behav, Orange, CA 92868 USA
Davis, Elysia Poggi
;
Muftuler, L. Tugan
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h-index: 0
机构:
Univ Calif Irvine, Dept Radiol Sci, Irvine, CA 92697 USAUniv Calif Irvine, Dept Psychiat & Human Behav, Orange, CA 92868 USA
Muftuler, L. Tugan
;
Head, Kevin
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机构:
Univ Calif Irvine, Dept Radiol Sci, Irvine, CA 92697 USAUniv Calif Irvine, Dept Psychiat & Human Behav, Orange, CA 92868 USA
Head, Kevin
;
Sandman, Curt A.
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机构:
Univ Calif Irvine, Dept Psychiat & Human Behav, Orange, CA 92868 USAUniv Calif Irvine, Dept Psychiat & Human Behav, Orange, CA 92868 USA
机构:Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
Bispham, J
;
Gopalakrishnan, GS
论文数: 0引用数: 0
h-index: 0
机构:Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
Gopalakrishnan, GS
;
Dandrea, J
论文数: 0引用数: 0
h-index: 0
机构:Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
Dandrea, J
;
Wilson, V
论文数: 0引用数: 0
h-index: 0
机构:Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
Wilson, V
;
Budge, H
论文数: 0引用数: 0
h-index: 0
机构:Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
Budge, H
;
Keisler, DH
论文数: 0引用数: 0
h-index: 0
机构:Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
Keisler, DH
;
Pipkin, FB
论文数: 0引用数: 0
h-index: 0
机构:Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
Pipkin, FB
;
Stephenson, T
论文数: 0引用数: 0
h-index: 0
机构:Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
Stephenson, T
;
Symonds, ME
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, EnglandUniv Nottingham Hosp, Queens Med Ctr, Acad Div Child Hlth, Sch Human Dev, Nottingham NG7 2UH, England
机构:
Univ So Calif, Childrens Hosp Los Angeles, Neurosci Program, Saban Res Inst, Los Angeles, CA 90027 USA
Univ Lille 2, INSERM, U837, Jean Pierre Aubert Res Ctr, Lille, FranceUniv So Calif, Childrens Hosp Los Angeles, Neurosci Program, Saban Res Inst, Los Angeles, CA 90027 USA
机构:
Univ Calif Irvine, Dept Psychiat & Human Behav, Orange, CA 92868 USAUniv Calif Irvine, Dept Psychiat & Human Behav, Orange, CA 92868 USA
Buss, Claudia
;
Davis, Elysia Poggi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Dept Psychiat & Human Behav, Orange, CA 92868 USA
Univ Calif Irvine, Dept Pediat, Irvine, CA 92697 USAUniv Calif Irvine, Dept Psychiat & Human Behav, Orange, CA 92868 USA
Davis, Elysia Poggi
;
Muftuler, L. Tugan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Dept Radiol Sci, Irvine, CA 92697 USAUniv Calif Irvine, Dept Psychiat & Human Behav, Orange, CA 92868 USA
Muftuler, L. Tugan
;
Head, Kevin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Dept Radiol Sci, Irvine, CA 92697 USAUniv Calif Irvine, Dept Psychiat & Human Behav, Orange, CA 92868 USA
Head, Kevin
;
Sandman, Curt A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Dept Psychiat & Human Behav, Orange, CA 92868 USAUniv Calif Irvine, Dept Psychiat & Human Behav, Orange, CA 92868 USA