Non-alcoholic Steatohepatitis Pathogenesis, Diagnosis, and Treatment

被引：25
|
作者：
Zhu, Bo [1 ]
Chan, Siu-Lung [1 ]
Li, Jack [1 ]
Li, Kathryn [1 ]
Wu, Hao [1 ]
Cui, Kui [1 ]
Chen, Hong [1 ]
机构：
[1] Harvard Med Sch, Boston Childrens Hosp, Dept Surg, Vasc Biol Program, Boston, MA 02115 USA
来源：
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 8卷
关键词：
non-alcohol fatty liver disease; non-alcoholic steatohepatitis; pathogenesis; diagnosis; treatment; FATTY LIVER-DISEASE; LONG NONCODING RNA; CONTROLLED ATTENUATION PARAMETER; HEPATIC LIPID-METABOLISM; LIFE-STYLE MODIFICATION; GUT MICROBIOTA; KUPFFER CELLS; HEPATOCELLULAR-CARCINOMA; TISSUE INHIBITOR; STELLATE CELLS;
D O I：
10.3389/fcvm.2021.742382
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
There has been a rise in the prevalence of non-alcohol fatty liver disease (NAFLD) due to the popularity of western diets and sedentary lifestyles. One quarter of NAFLD patients is diagnosed with non-alcoholic steatohepatitis (NASH), with histological evidence not only of fat accumulation in hepatocytes but also of liver cell injury and death due to long-term inflammation. Severe NASH patients have increased risks of cirrhosis and liver cancer. In this review, we discuss the pathogenesis and current methods of diagnosis for NASH, and current status of drug development for this life-threatening liver disease.
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页数：13
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