Revisiting the impact of lifestyle on colorectal cancer risk in a gender perspective

被引:37
作者
Conti, Lucia [1 ]
Del Como, Manuela [1 ]
Gessani, Sandra [1 ]
机构
[1] Ist Super Sanita, Ctr Gender Specif Med, Viale Regina Elena 299, I-00161 Rome, Italy
关键词
Lifestyle; Gender; Sex; Colorectal cancer; Risk factor; Diet; Physical activity; 12-MONTH EXERCISE INTERVENTION; RECREATIONAL PHYSICAL-ACTIVITY; DIETARY INFLAMMATORY INDEX; COLON-CANCER; RECTAL-CANCER; MEDITERRANEAN DIET; SEDENTARY BEHAVIOR; ENERGY-EXPENDITURE; BODY-COMPOSITION; ADIPOSE-TISSUE;
D O I
10.1016/j.critrevonc.2019.102834
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Colorectal cancer (CRC) is a leading cause of cancer-related mortality in the world. Patterns and trends in CRC incidence and mortality correlate with increasing adoption of Western lifestyles and with the overweight/obesity epidemic. Both genetic background and a range of modifiable environmental/lifestyle factors play a role in CRC etiology. Among these the links of body weight, dietary patterns and physical activity (PA) behavior with CRC risk are some of the strongest for any type of cancer, with a different impact in women and men. Nonetheless, gender disparities still represent a neglected aspect of CRC management. This review sheds light on gender-related association of obesity and different dietary/PA habits with CRC risk, highlighting the importance of lifestyle modifications in the prevention of this neoplastic disease. In this scenario, intervention studies are strongly recommended to define the most effective dietary/PA regimens for primary prevention of cancer in women and men.
引用
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页数:8
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