HIV-infected patients aged above 75 years

Background. - Little data is available on HIV-infected patients aged over 75 years. Methods. - A descriptive study of HIV-infected patients aged over 75 years was conducted in six hospitals of the Pays de la Loire region, France. Socio-demographic, immuno-virological, and therapeutic characteristics were collected via an electronic medical record software (Nadis (R)). To assess frailty, a simplified geriatric assessment was conducted during an HIV routine visit. Results. - Among the 3965 patients followed in the six centers, 65 (1.6%) were aged over 75 years. From January to May 2016, 51 patients were included in the study: median age 78.7 years, male patients 74.5%, homosexual transmission 41.2%, living at home 98% and single in 54.5% of cases, median duration of HIV infection 18.8 years, median CD4 nadir 181 cells/mm(3); CDC stage C 36.4%. All patients were on antiretroviral therapy and 98% of them had an HIV RNA <50 c/mL; 82% of patients had at least one comorbidity and 58% at least two comorbidities. Eleven of 51 patients (21.6%) were diagnosed as at risk of frailty and 2/51 (3.9%) were considered frail. Cognitive disorders were diagnosed in 60.8%, depression in 35.3%, malnutrition in 25.5%, and vitamin D deficiency in 45.9%. Conclusions. - HIV-infected patients aged above 75 years are well-managed, but the prevalence of geriatric comorbidities is high. (C) 2019 Elsevier Masson SAS. All rights reserved.