The world now is in a period of globalization, the development of science and technology, especially the development of information technology has promoted the development and changes of educational in higher vocational colleges. Influenced by the frequent development of computer and internet technology, the construction of education modernization has developed into a deeper level. In recent years, the emergence and development of Mooc brings both new opportunities and challenges to the personnel training in the field of higher vocational education. The educational reform of Mooc provide higher requirements for teachers in higher vocational colleges, and to respect and make adaptations to the personalities and laws of development of students is a research topic urgently needed by higher vocational colleges. Therefore, this paper studies the teaching in higher vocational colleges by combining information technology with traditional methods, and proposes some applicable strategies in order to promote the teaching in higher vocational colleges by making use of information technology on the basis of Mooc.