PROSPECTIVE RANDOMIZED DOUBLE-BLIND PILOT STUDY OF SITE-SPECIFIC CONSENSUS ATLAS IMPLEMENTATION FOR RECTAL CANCER TARGET VOLUME DELINEATION IN THE COOPERATIVE GROUP SETTING

被引：69

作者：

Fuller, Clifton D. ^{[1
,2
,3
]}

Nijkamp, Jasper ^{[4
]}

Duppen, Joop C. ^{[4
]}

Rasch, Coen R. N. ^{[4
]}

Thomas, Charles R., Jr. ^{[3
]}

Wang, Samuel J. ^{[3
]}

Okunieff, Paul ^{[5
]}

Jones, William E., III ^{[1
]}

Baseman, Daniel ^{[1
]}

Patel, Shilpen ^{[6
]}

Demandante, Carlo G. N. ^{[1
,7
]}

Harris, Anna M. ^{[1
]}

Smith, Benjamin D. ^{[8
,9
]}

Katz, Alan W. ^{[5
]}

McGann, Camille ^{[9
]}

Harper, Jennifer L. ^{[10
]}

Chang, Daniel T. ^{[11
]}

Smalley, Stephen ^{[12
,13
]}

Marshall, David T. ^{[10
]}

Goodman, Karyn A. ^{[14
]}

Papanikolaou, Niko ^{[1
,2
]}

Kachnic, Lisa A. ^{[15
,16
]}

机构：

[1] Univ Texas San Antonio, Hlth Sci Ctr San Antonio, Dept Radiat Oncol, San Antonio, TX USA

[2] Univ Texas San Antonio, Grad Div Radiol Sci, Dept Radiol, San Antonio, TX USA

[3] Oregon Hlth & Sci Univ, Dept Radiat Med, Portland, OR 97201 USA

[4] Netherlands Canc Inst, Dept Radiotherapy, Amsterdam, Netherlands

[5] Univ Rochester, Dept Radiat Oncol, Rochester, NY USA

[6] Univ Washington, Med Ctr, Dept Radiat Oncol, Seattle, WA 98195 USA

[7] Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA

[8] Univ Texas Houston, MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

[9] Brooke Army Med Ctr, Dept Radiat Oncol, San Antonio, TX USA

[10] Med Univ S Carolina, Dept Radiat Oncol, Charleston, SC 29425 USA

[11] Stanford Univ, Dept Radiat Oncol, Stanford, CA 94305 USA

[12] Univ Kansas, Dept Radiat Oncol, Kansas City, KS USA

[13] Radiat Oncol Ctr Olathe, Olathe, KS USA

[14] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10021 USA

[15] Boston Univ, Med Ctr, Dept Radiat Oncol, Boston, MA USA

[16] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2011年 / 79卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Target volume delineation; Cooperative group; Conformal radiotherapy; Atlas; Consensus guideline; HEAD-AND-NECK; CONFORMAL RADIOTHERAPY; RADIATION ONCOLOGY; IMAGE REGISTRATION; DUMMY RUN; IMPACT; CT; VARIABILITY; DEFINITION; PROSTATE;

D O I：

10.1016/j.ijrobp.2009.11.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: Variations in target volume delineation represent a significant hurdle in clinical trials involving conformal radiotherapy. We sought to determine the effect of a consensus guideline-based visual atlas on contouring the target volumes. Methods and Materials: A representative case was contoured (Scan 1) by 14 physician observers and a reference expert with and without target volume delineation instructions derived from a proposed rectal cancer clinical trial involving conformal radiotherapy. The gross tumor volume (GTV), and two clinical target volumes (CTVA, including the internal iliac, presacral, and perirectal nodes, and CTVB, which included the external iliac nodes) were contoured. The observers were randomly assigned to receipt (Group A) or nonreceipt (Group B) of a consensus guideline and atlas for anorectal cancers and then instructed to recontour the same case/images (Scan 2). Observer variation was analyzed volumetrically using the conformation number (CN, where CN = 1 equals total agreement). Results: Of 14 evaluable contour sets (1 expert and 7 Group A and 6 Group B observers), greater agreement was found for the GTV (mean CN, 0.75) than for the CTVs (mean CN, 0.46-0.65). Atlas exposure for Group A led to significantly increased interobserver agreement for CTVA (mean initial CN, 0.68, after atlas use, 0.76; p = .03) and increased agreement with the expert reference (initial mean CN, 0.58; after atlas use, 0.69; p = .02). For the GTV and CTVB, neither the interobserver nor the expert agreement was altered after atlas exposure. Conclusion: Consensus guideline atlas implementation resulted in a detectable difference in interobserver agreement and a greater approximation of expert volumes for the CTVA but not for the GTV or CTVB in the specified case. Visual atlas inclusion should be considered as a feature in future clinical trials incorporating conformal RT. (C) 2011 Elsevier Inc.

引用

页码：481 / 489

页数：9

共 1 条

[1] Prospective randomized double-blind study of atlas-based organ-at-risk autosegmentation-assisted radiation planning in head and neck cancer
Walker, Gary V.
Awan, Musaddiq
Tao, Randa
Koay, Eugene J.
Boehling, Nicholas S.
Grant, Jonathan D.
Sittig, Dean F.
Gunn, Gary Brandon
Garden, Adam S.
Jack Phan
Morrison, William H.
Rosenthal, David I.
Mohamed, Abdallah Sherif Radwan
Fuller, Clifton David
RADIOTHERAPY AND ONCOLOGY, 2014, 112 (03) : 321 - 325

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