A novel aspochalasin with HIV-1 integrase inhibitory activity from Aspergillus flavipes

被引：44
作者：
Rochfort, S
Ford, J
Ovenden, S
Wan, SS
George, S
Wildman, H
Tait, RM
Meurer-Grimes, B
Cox, S
Coates, J
Rhodes, D
机构：
[1] Cerylid Biosci, Richmond, Vic 3121, Australia
[2] Amrad Corp Ltd, Richmond, Vic 3121, Australia
来源：
JOURNAL OF ANTIBIOTICS | 2005年 / 58卷 / 04期
关键词：
Aspergillus flavipes; aspochalasin; HIV integrase; cytochalasins;
D O I：
10.1038/ja.2005.34
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
sA novel aspochalasin, aspochalasin L (1), was isolated from the fermentation broth of a soil-derived fungal culture identified as Aspergillus flavipes (Deuteromycota). Structure elucidation of 1 was accomplished by detailed spectroscopic data analyses and by comparison with related cytochalasins. Aspochalasin L demonstrated activity against HIV integrase with an IC50 of 71.7 mu M.
引用
收藏
页码：279 / 283
页数：5
相关论文
共 45 条
[41]   Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones [J].
Zhao, Xue Zhi ;
Maddali, Kasthuraiah ;
Vu, B. Christie ;
Marchand, Christophe ;
Hughes, Stephen H. ;
Pommier, Yves ;
Burke, Terrence R., Jr. .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (10) :2714-2717
[42]   The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitness [J].
Wares, Melissa ;
Mesplede, Thibault ;
Quashie, Peter K. ;
Osman, Nathan ;
Han, Yingshan ;
Wainberg, Mark A. .
RETROVIROLOGY, 2014, 11
[43]   The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitness [J].
Melissa Wares ;
Thibault Mesplède ;
Peter K Quashie ;
Nathan Osman ;
Yingshan Han ;
Mark A Wainberg .
Retrovirology, 11
[44]   Dolutegravir in antiretroviral-naive adults with HIV-1: 96-week results from a randomized dose-ranging study [J].
Stellbrink, Hans-Juergen ;
Reynes, Jacques ;
Lazzarin, Adriano ;
Voronin, Eugene ;
Pulido, Federico ;
Felizarta, Franco ;
Almond, Steve ;
St Clair, Marty ;
Flack, Nancy ;
Min, Sherene .
AIDS, 2013, 27 (11) :1771-1778
[45]   Synthesis and HIV-integrase strand transfer inhibition activity of 7-hydroxy[1,3]thiazolo[5,4-b]pyridin-5(4H)-ones [J].
Boros, Eric E. ;
Johns, Brian A. ;
Garvey, Edward P. ;
Koble, Cecilia S. ;
Miller, Wayne H. .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (21) :5668-5672
12345