A novel aspochalasin with HIV-1 integrase inhibitory activity from Aspergillus flavipes

被引：44

作者：

Rochfort, S

Ford, J

Ovenden, S

Wan, SS

George, S

Wildman, H

Tait, RM

Meurer-Grimes, B

Cox, S

Coates, J

Rhodes, D

机构：

[1] Cerylid Biosci, Richmond, Vic 3121, Australia

[2] Amrad Corp Ltd, Richmond, Vic 3121, Australia

来源：

JOURNAL OF ANTIBIOTICS | 2005年 / 58卷 / 04期

关键词：

Aspergillus flavipes; aspochalasin; HIV integrase; cytochalasins;

D O I：

10.1038/ja.2005.34

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

sA novel aspochalasin, aspochalasin L (1), was isolated from the fermentation broth of a soil-derived fungal culture identified as Aspergillus flavipes (Deuteromycota). Structure elucidation of 1 was accomplished by detailed spectroscopic data analyses and by comparison with related cytochalasins. Aspochalasin L demonstrated activity against HIV integrase with an IC50 of 71.7 mu M.

引用

页码：279 / 283

页数：5

共 45 条

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