A novel aspochalasin with HIV-1 integrase inhibitory activity from Aspergillus flavipes

被引：44
|
作者：
Rochfort, S
Ford, J
Ovenden, S
Wan, SS
George, S
Wildman, H
Tait, RM
Meurer-Grimes, B
Cox, S
Coates, J
Rhodes, D
机构：
[1] Cerylid Biosci, Richmond, Vic 3121, Australia
[2] Amrad Corp Ltd, Richmond, Vic 3121, Australia
来源：
JOURNAL OF ANTIBIOTICS | 2005年 / 58卷 / 04期
关键词：
Aspergillus flavipes; aspochalasin; HIV integrase; cytochalasins;
D O I：
10.1038/ja.2005.34
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
sA novel aspochalasin, aspochalasin L (1), was isolated from the fermentation broth of a soil-derived fungal culture identified as Aspergillus flavipes (Deuteromycota). Structure elucidation of 1 was accomplished by detailed spectroscopic data analyses and by comparison with related cytochalasins. Aspochalasin L demonstrated activity against HIV integrase with an IC50 of 71.7 mu M.
引用
收藏
页码：279 / 283
页数：5
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