Concise Total Synthesis of Sintokamides A, B, and E by a Unified, Protecting-Group-Free Strategy

被引：86
|
作者：
Gu, Zhenhua [1 ]
Zakarian, Armen [1 ]
机构：
[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 50期
基金：
美国国家卫生研究院;
关键词：
chlorine; natural products; peptides; total synthesis; trichloromethylation; MARINE NATURAL-PRODUCTS; KETENE SILYL ACETALS; TETRAMIC ACIDS; BARBAMIDE BIOSYNTHESIS; PEPTIDE-SYNTHESIS; DYSIDEA SP; ANALOGS; HALOGENATION; REBECCAMYCIN; DERIVATIVES;
D O I：
10.1002/anie.201005354
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
One for all: A group of polychlorinated marine peptides known as sintokamides show intriguing activity against hormone-refractory prostate cancer cells. Three members of the group have now been synthesized by a general strategy enabled by a ruthenium-catalyzed radical chloroalkylation of titanium enolates (see scheme). Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：9702 / 9705
页数：4
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