Maternal and neonatal bleeding complications in relation to peripartum management in women with Von Willebrand disease: A systematic review

被引：33

作者：

Punt, M. C. ^{[1
]}

Waning, M. L. ^{[1
]}

Mauser-Bunschoten, E. P. ^{[1
]}

Kruip, M. J. H. A. ^{[2
]}

Eikenboom, J. ^{[3
]}

Nieuwenhuizen, L. ^{[4
]}

Makelburg, A. B. U. ^{[5
]}

Driessens, M. H. E. ^{[6
]}

Duvekot, J. J. ^{[7
]}

Peters, M. ^{[8
]}

Middeldorp, J. M. ^{[9
]}

Bloemenkamp, K. W. M. ^{[10
]}

Schutgens, R. E. G. ^{[1
]}

Lely, A. T. ^{[10
]}

Van Galen, K. P. M. ^{[11
]}

机构：

[1] Univ Utrecht, Univ Med Ctr Utrecht, Van Creveldklin, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[2] Erasmus MC, Dept Hematol, Doctor Molewaterpl 40, NL-3015 GD Rotterdam, Netherlands

[3] Leiden Univ, Med Ctr, Dept Internal Med, Div Thrombosis & Hemostasis, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands

[4] Maxima Med Ctr, Dept Internal Med, Run 4600, NL-5504 DB Veldhoven, Netherlands

[5] Univ Med Ctr Groningen, Dept Hematol, Hanzepl 1, NL-9713 GZ Groningen, Netherlands

[6] Netherlands Hemophilia Patient Soc, Stn Weg 6b, NL-3862 CG Nijkerk, Netherlands

[7] Erasmus MC, Dept Gynaecol & Obstet, Doctor Molewaterpl 40, NL-3015 GD Rotterdam, Netherlands

[8] Univ Med Ctr, Emma Childrens Hosp, Locat AMC, Dept Pediat Hematol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

[9] Leiden Univ, Med Ctr, Dept Obstet, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands

[10] Univ Med Ctr Utrecht, Dept Gynaecol & Obstet, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[11] Univ Utrecht, Univ Med Ctr Utrecht, Van Creveldklin, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

来源：

BLOOD REVIEWS | 2020年 / 39卷

关键词：

von Willebrand disease; Pregnancy; Peripartum period; Postpartum hemorrhage; Prophylactic treatment; EPIDURAL LABOR ANALGESIA; VONWILLEBRANDS-DISEASE; POSTPARTUM HEMORRHAGE; FACTOR-VIII; CLINICAL-MANIFESTATIONS; SEVERE THROMBOCYTOPENIA; OBSTETRIC MANAGEMENT; REFERENCE INTERVALS; PREGNANT PATIENT; HEMOPHILIA-A;

D O I：

10.1016/j.blre.2019.100633

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Women with Von Willebrand disease (VWD) have an increased risk of developing postpartum hemorrhage (PPH). Our aim is to evaluate peripartum management strategies in relation to maternal and neonatal bleeding complications in VWD. Electronic databases were searched up to January 2019. Seventy-one case-reports and series and 16 cohort studies were selected, including 811 deliveries. Cohort studies reported primary PPH in 32% and secondary PPH in 13% of the women. The overall primary PPH incidence in the individual patient data was 34%, similar between women who received prophylactic treatment to prevent PPH and those who didn't. Neonatal bleeding events were reported in 4.6% of deliveries. Overall, the available evidence on peripartum management in women with VWD was of low quality. The ongoing high risk for PPH is evident, despite prophylactic treatment, as well as the need for higher quality evidence from larger prospective cohort studies to improve management strategies.

引用

页数：9

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