Scale-up of filamentous organisms from tubes and shake-flasks into stirred vessels

被引：20

作者：

Katzer, W ^{[1
]}

Blackburn, M ^{[1
]}

Charman, K ^{[1
]}

Martin, S ^{[1
]}

Penn, J ^{[1
]}

Wrigley, S ^{[1
]}

机构：

[1] TerraGen Discovery UK Ltd, Slough, Berks, England

来源：

BIOCHEMICAL ENGINEERING JOURNAL | 2001年 / 7卷 / 02期

关键词：

filamentous organism; fungi; antinomycetes; tubes; shake-flask; secondary metabolite; fermentation;

D O I：

10.1016/S1369-703X(00)00112-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The choice of small-scale fermentation systems contributes significantly to a successful scale-up. Creasing of flasks and the chosen shaker parameters influence the production of secondary metabolites in a strain- and even compound-specific manner. Using actinomycetes and fungi as model organisms the influence of the small-scale fermentation system on the production of various secondary metabolites is described and the effects on screening success and scale-up are considered. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：127 / 134

页数：8

共 7 条

[1] XENOVULENE-A, A NOVEL GABA-BENZODIAZEPINE RECEPTOR-BINDING COMPOUND PRODUCED BY ACREMONIUM-STRICTUM [J].

AINSWORTH, AM ;

CHICARELLIROBINSON, MI ;

COPP, BR ;

FAUTH, U ;

HYLANDS, PJ ;

HOLLOWAY, JA ;

LATIF, M ;

OBEIRNE, GB ;

PORTER, N ;

RENNO, DV ;

RICHARDS, M ;

ROBINSON, N .

JOURNAL OF ANTIBIOTICS, 1995, 48 (07) :568-573

[2] Inhibition of plasminogen activator inhibitor-1 activity by two diketopiperazines, XR330 and XR334 produced by Streptomyces sp. [J].

Bryans, J ;

Charlton, P ;

ChicarelliRobinson, I ;

Collins, M ;

Faint, R ;

Latham, C ;

Shaw, I ;

Trew, S .

JOURNAL OF ANTIBIOTICS, 1996, 49 (10) :1014-1021

[3]

DELGADO G, 1989, APPL MICROBIOL BIOT, V31, P288

[4]

MCDANIEL LE, 1968, APPL MICROBIOL, V17, P286

[5]

SUMINO Y, 1993, APPL MICROBIOL BIOT, V38, P581

[6] HIGH-AERATION CAPACITY SHAKE-FLASK SYSTEM [J].

TUNAC, JB .

JOURNAL OF FERMENTATION AND BIOENGINEERING, 1989, 68 (02) :157-159

[7] A novel (6S)-4,6-dimethyldodeca-2E,4E-dienoyl ester of phomalactone and related α-pyrone esters from a Phomopsis sp with cytokine production inhibitory activity [J].

Wrigley, SK ;

Sadeghi, R ;

Bahl, S ;

Whiting, AJ ;

Ainsworth, AM ;

Martin, SM ;

Katzer, W ;

Ford, R ;

Kau, DA ;

Robinson, N ;

Hayes, MA ;

Elcock, C ;

Mander, T ;

Moore, M .

JOURNAL OF ANTIBIOTICS, 1999, 52 (10) :862-872

← 1 →