Taking aim at translation for tumor therapy

被引：19

作者：

Barnhart, Bryan C.

Simon, M. Celeste

机构：

[1] Univ Penn, Sch Med, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

[2] Univ Penn, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Dept Canc Biol, Philadelphia, PA 19104 USA

[4] Univ Penn, Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2007年 / 117卷 / 09期

关键词：

D O I：

10.1172/JCI33107

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Increased cap-dependent mRNA translation rates are frequently observed in human cancers. Mechanistically, many human tumors often overexpress the cap binding protein eukaryotic translation initiation factor 4E (eIF4E), leading to enhanced translation of numerous tumor-promoting genes. In this issue of the JCI, Graff and colleagues describe potent antitumor effects using second-generation antisense oligonucleotides for eIF4E (see the related article beginning on page 2638). If their results are recapitulated in a clinical setting, this strategy will provide a promising antitumor therapy with broad-reaching applications.

引用

收藏

页码：2385 / 2388

页数：4

相关论文

共 16 条

[1] A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets [J].

Arsham, AM ;

Howell, JJ ;

Simon, MC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (32) :29655-29660

[2] Lost in translation: Dysregulation of cap-dependent translation and cancer [J].

Bjornsti, MA ;

Houghton, PJ .

CANCER CELL, 2004, 5 (06) :519-523

[3] The TOR pathway: A target for cancer therapy [J].

Bjornsti, MA ;

Houghton, PJ .

NATURE REVIEWS CANCER, 2004, 4 (05) :335-348

[4] Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin [J].

Brunn, GJ ;

Hudson, CC ;

Sekulic, A ;

Williams, JM ;

Hosoi, H ;

Houghton, PJ ;

Lawrence, JC ;

Abraham, RT .

SCIENCE, 1997, 277 (5322) :99-101

[5] eIF-4E expression and its role in malignancies and metastases [J].

De Benedetti, A ;

Graff, JR .

ONCOGENE, 2004, 23 (18) :3189-3199

[6] Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E [J].

Fingar, DC ;

Salama, S ;

Tsou, C ;

Harlow, E ;

Blenis, J .

GENES & DEVELOPMENT, 2002, 16 (12) :1472-1487

[7] mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E [J].

Fingar, DC ;

Richardson, CJ ;

Tee, AR ;

Cheatham, L ;

Tsou, C ;

Blenis, J .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (01) :200-216

[8] Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity [J].

Graff, Jeremy R. ;

Konicek, Bruce W. ;

Vincent, Thomas M. ;

Lynch, Rebecca L. ;

Monteith, David ;

Weir, Spring N. ;

Schwier, Phil ;

Capen, Andrew ;

Goode, Robin L. ;

Dowless, Michele S. ;

Chen, Yuefeng ;

Zhang, Hong ;

Sissons, Sean ;

Cox, Karen ;

McNulty, Ann M. ;

Parsons, Stephen H. ;

Wang, Tao ;

Sams, Lillian ;

Geeganage, Sandaruwan ;

Douglass, Larry E. ;

Neubauer, Blake Lee ;

Dean, Nicholas M. ;

Blanchard, Kerry ;

Shou, Jianyong ;

Stancato, Louis F. ;

Carter, Julia H. ;

Marcusson, Eric G. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (09) :2638-2648

[9]

GRAFF JR, 1995, INT J CANCER, V60, P255

[10] mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events [J].

Holz, MK ;

Ballif, BA ;

Gygi, SP ;

Blenis, J .

CELL, 2005, 123 (04) :569-580