Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Associated with Acetaminophen Use during Viral Infections

被引：17
作者：
Ban, Ga-Young [1 ,2 ]
Ahn, Seun-Joo [1 ]
Yoo, Hye-Soo [1 ]
Park, Hae-Sim [1 ]
Ye, Young-Min [1 ,2 ]
机构：
[1] Ajou Univ, Sch Med, Dept Allergy & Clin Immunol, Suwon 16499, South Korea
[2] Ajou Univ Hosp, Ajou Reg Pharmacovigilance Ctr, Suwon 16499, South Korea
来源：
IMMUNE NETWORK | 2016年 / 16卷 / 04期
关键词：
Severe cutaneous adverse reaction; Acetaminophen; Viral infection; DRUG ALLERGY;
D O I：
10.4110/in.2016.16.4.256
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
An association between drug treatment for viral infections and severe cutaneous adverse reactions has been noted. We investigated six patients diagnosed with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) after being prescribed acetaminophen for suspected viral illnesses. Multiplex analysis was performed to measure cytokine levels in sera before and after treatment. IL-2R alpha levels significantly decreased during the convalescence phase. Although acetaminophen is relatively safe, the drug can trigger SJS/TEN in patients with suspected viral infections. T-cells and monocytes may be key components of the link between viral infection and acetaminophen-induced SJS/TEN.
引用
收藏
页码：256 / 260
页数：5
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