The impact of preanalytical variables on measuring cerebrospinal fluid biomarkers for Alzheimer's disease diagnosis: A review

被引：96

作者：

Hansson, Oskar ^{[1
,2
]}

Mikulskis, Alvydas ^{[3
]}

Fagan, Anne M. ^{[4
]}

Teunissen, Charlotte ^{[5
]}

Zetterberg, Henrik ^{[6
,7
,8
,9
]}

Vanderstichele, Hugo ^{[10
]}

Molinuevo, Jose Luis ^{[11
]}

Shaw, Leslie M. ^{[12
]}

Vandijck, Manu ^{[13
]}

Verbeek, Marcel M. ^{[14
,15
]}

Savage, Mary ^{[16
]}

Mattsson, Niklas ^{[1
]}

Lewczuk, Piotr ^{[17
,18
,19
]}

Batrla, Richard ^{[20
]}

Rutz, Sandra ^{[21
]}

Dean, Robert A. ^{[22
]}

Blennow, Kaj ^{[8
,9
]}

机构：

[1] Skane Univ Hosp, Dept Neurol, Lund, Sweden

[2] Skane Univ Hosp, Memory Clin, Malmo, Sweden

[3] Biogen, Boston, MA USA

[4] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[5] Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands

[6] UK Dementia Res Inst, London, England

[7] UCL Inst Neurol, Dept Mol Neurosci, London, England

[8] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[9] Univ Gothenburg, Sahlgrenska Acad, Dept Psychiat & Neurochem, Molndal, Sweden

[10] ADx NeuroSci, Ghent, Belgium

[11] Pasqual Maragall Fdn, BarcelonaBeta Brain Res Ctr, Barcelona, Spain

[12] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA

[13] Fujirebio Europe NV, Ghent, Belgium

[14] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Neurol, Nijmegen, Netherlands

[15] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Lab Med, Nijmegen, Netherlands

[16] Merck & Co Inc, West Point, PA USA

[17] Univ Klinikum Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany

[18] Friedrich Alexander Univ Erlangen Nurnberg, Erlangen, Germany

[19] Med Univ Bialystok, Dept Neurodegenerat Diagnost, Bialystok, Poland

[20] Roche Diagnost GmbH, Rotkreuz, Switzerland

[21] Roche Diagnost GmbH, Penzberg, Germany

[22] Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA

来源：

ALZHEIMERS & DEMENTIA | 2018年 / 14卷 / 10期

基金：

荷兰研究理事会; 英国医学研究理事会; 瑞典研究理事会; 欧洲研究理事会; 美国国家卫生研究院;

关键词：

Cerebrospinal fluid; Biomarkers; Preanalytical variables; Alzheimer's disease diagnosis; beta-Amyloid; 42; Total tau; Phosphorylated tau; MILD COGNITIVE IMPAIRMENT; BETA-AMYLOID; 1-42; STANDARD OPERATING PROCEDURES; CSF A-BETA; PHOSPHORYLATED TAU; CLINICAL UTILITY; ASSOCIATION WORKGROUPS; NATIONAL INSTITUTE; APOLIPOPROTEIN-E; LUMBAR PUNCTURE;

D O I：

10.1016/j.jalz.2018.05.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Cerebrospinal fluid (CSF) biomarkers have the potential to improve the diagnostic accuracy of Alzheimer's disease, yet there is a lack of harmonized preanalytical CSF handling protocols. Methods: This systematic review summarizes the current literature on the influence of preanalytical variables on CSF biomarker concentration. We evaluated the evidence for three core CSF biomarkers: beta-amyloid 42, total tau, and phosphorylated tau. Results: The clinically important variables with the largest amount of conflicting data included the temperature at which samples are stored, the time nonfrozen samples can be stored, and possible effects of additives such as detergents, blood contamination, and centrifugation. Conversely, we discovered that there is consensus that tube material has a significant effect. Discussion: A unified CSF handling protocol is recommended to reduce preanalytical variability and facilitate comparison of CSF biomarkers across studies and laboratories. In future, experiments should use a gold standard with fresh CSF collected in low binding tubes. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：1313 / 1333

页数：21

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