Influence of pore sizes in 3D-scaffolds on mechanical properties of scaffolds and survival, distribution, and proliferation of human chondrocytes

被引：27

作者：

Abpeikar, Zahra ^{[1
]}

Milan, Peiman Brouki ^{[2
,3
]}

Moradi, Lida ^{[4
,5
]}

Anjomshoa, Maryam ^{[6
]}

Asadpour, Shiva ^{[1
,7
]}

机构：

[1] Shahrekord Univ Med Sci, Sch Adv Technol, Dept Tissue Engn & Appl Cell Sci, Shahrekord, Iran

[2] Iran Univ Med Sci, Cellular & Mol Res Ctr, Tehran, Iran

[3] Iran Univ Med Sci, Fac Adv Technol Med, Dept Tissue Engn & Regenerat Med, Tehran, Iran

[4] NYU, Med Sch, Dept Orthoped Surg, New York, NY USA

[5] NYU, Med Sch, Dept Cell Biol, New York, NY USA

[6] Shahrekord Univ Med Sci, Fac Med, Dept Anat Sci, Shahrekord, Iran

[7] Shahrekord Univ Med Sci, Cellular & Mol Res Ctr, Basic Hlth Sci Inst, Shahrekord, Iran

来源：

MECHANICS OF ADVANCED MATERIALS AND STRUCTURES | 2022年 / 29卷 / 26期

关键词：

Cartilage tissue engineering; mechanical properties; polycaprolactone; pore size; scaffold; ARTICULAR-CARTILAGE; FLUID-FLOW; CELL-GROWTH; TISSUE; DIFFERENTIATION; BONE; POROSITY; DECELLULARIZATION; ADHESION; BEHAVIOR;

D O I：

10.1080/15376494.2021.1943077

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Articular cartilage has weak intrinsic self-healing capacity. Tissue engineering is an appropriate option for cartilage regeneration. This research was designed to evaluate the effects of pore size in scaffolds on mechanical properties and chondrocyte-scaffold interactions. PCL scaffolds were fabricated with large, medium, and small pore sizes. The constructs were analyzed by SEM, swelling tests, mechanical tests, MTT assay, and H&E staining after chondrocyte seeding. Mechanical features of the scaffolds were near to human articular cartilage. Our findings suggest that the PCL scaffold with medium pore sizes provides suitable mechanical strength and better chondrocyte-scaffold interactions simultaneously for application in cartilage.

引用

页码：4911 / 4922

页数：12

共 59 条

[1] Macroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair [J].